| 2型糖尿病患者非糖尿病一级亲属血清高敏C反应蛋白与胰岛素抵抗的相关性 |
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| 引用本文： | 邓晨昕,高凌,张海荣,曾照琼.2型糖尿病患者非糖尿病一级亲属血清高敏C反应蛋白与胰岛素抵抗的相关性[J].中华糖尿病杂志,2008,16(7):413-415. |
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| 作者姓名： | 邓晨昕 高凌 张海荣 曾照琼 |
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| 作者单位： | [1]襄樊市中心医院内分泌科,湖北441021 [2]襄樊市中心医院检验科,湖北441021 |
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| 摘 要： | 目的探讨血清高敏C反应蛋白（hsC-RP）在2型糖尿病（T2DM）发病中的作用。方法利用ELISA方法检测72例T2DM患者非糖尿病一级亲属（FDR）和68例健康对照者（NC）血清hsC-RP、Fins、FPG等，并用HOMA—IR公式计算胰岛素抵抗指数。结果（1）FDR组血清hsC—RP水平较NC组升高（P〈0.01），HOMA—IR高于NC组（P〈0.01）；（2）血清hsC-RP水平与HOMA-IR（r=0．307，P〈0．01）、Fins（r=0．286，P〈0．05）、BMI（r=0．250，P〈0．05）、LDL—C（r=0．302，P〈0．05）、TC（r=0．267，P〈0．05）相关。结论慢性炎症与胰岛素抵抗密切相关，hsC-RP升高是2型糖尿病发生的一个预测因子。
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| 关 键 词： | 糖尿病 C反应蛋白 胰岛素抵抗 |
Relation of high-sensitivity C-reactive protein with insulin resistance in the first-degree relatives of type 2 diabetics |
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| Institution: | DENG Chen-xin , GAO Ling, ZHANG Hai-rong , et al. (Department of Endocrinology, Xiang-fan Central Hospital, Affiliated to Tongji Medical College , Huazhong University of Science and Technology, Xiangfan 441021, China) |
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| Abstract: | Objective To explore the possible pathogenesis of type 2 diabetes. Methods Serum samples were collected from 72 first-degree relatives of type 2 diabetic subjects and 68 normal subjects. Results Circulation levels of high-sensitivity C-reactive protein （hsCRP） and insulin resistance index estimated by homeostasis model assessment （HOMA-IR） were significantly higher in first-degree relatives than in controls （P 〈 0.01）. Circulation levels of hsCRP was correlated to HOMA-IR （r = 0. 307, P 0.01） ,fasting insulin （Fins） （r=0. 286,P〈0. 05）, body mass index （BMI） （r=0. 250, P〈0.05） ,low-density lipoprotein cholesterol （LDL-C） （r=0. 302, P〈0.05） and total cholesterol（TC） （r=0. 267, P〈 0.05）. Conclusions The data support the hypothesis that low-grade systemic inflammation is associated with insulin resistance, hsCRP is a strong predictor for the development of type 2 diabetes. |
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| Keywords: | Diabetes mellitus C-reactive protein Insulin resistance |
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