首页 | 本学科首页   官方微博 | 高级检索  
检索        


Transient seizure activity induced by acetylcarnitine
Authors:R G Fariello  E Zeeman  G T Golden  P T Reyes  T Ramacci
Institution:1. Research and Neurology Services, Veterans Administration Hospital Coatesville, Pennsylvania 19320, USA;2. Department of Neurology and Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107 USA;3. Sigma Tau Pharmaceutical Co., Pomezia, Roma, ITALY
Abstract:Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency of 40-90 min. Acetylcarnitine epileptogenic properties are probably related to muscarinic agonism. The transition from interictal to ictal events may involve failure of GABAergic mechanisms.
Keywords:
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号