Transient seizure activity induced by acetylcarnitine |
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Authors: | R G Fariello E Zeeman G T Golden P T Reyes T Ramacci |
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Institution: | 1. Research and Neurology Services, Veterans Administration Hospital Coatesville, Pennsylvania 19320, USA;2. Department of Neurology and Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107 USA;3. Sigma Tau Pharmaceutical Co., Pomezia, Roma, ITALY |
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Abstract: | Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency of 40-90 min. Acetylcarnitine epileptogenic properties are probably related to muscarinic agonism. The transition from interictal to ictal events may involve failure of GABAergic mechanisms. |
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