不同阶段血管性认知功能障碍患者事件相关电位P300的特点

目的:探讨不同阶段血管性认知功能障碍(VCI)患者的听觉ERP-P300特点,以为其早期诊断提供客观依据。方法:根据VCI诊断标准选取血管性痴呆(VaD)、无痴呆的血管认知功能障碍(VCIND)患者各50例,并以认知功能正常的脑血管病患者50例为对照组,分别对其进行听觉ERP-P300检测。结果:(1)与对照组相比VCIND组P300潜伏期、N200-P300波间期延长,P300波幅减低;VaD组N200、P300潜伏期,P200-N200、N200-P300波间期明显延长,P300波幅减低,差异有统计学意义。(2)所有患者N200、P300潜伏期与性别无关,与MMSE分数呈负相关,P300潜伏期与年龄正相关。结论:VCIND组患者的ERP-P300特点为P300潜伏期、N200-P300波间期延长,P300波幅减低;VaD组除上述特点外,N200潜伏期、P200-N200波间期延长。ERP-P300对VCI有一定的早期诊断价值。

The Features of Event-Related Potential P300 in Patients with Different Stages of Vascular Cognitive Impairment

Objective: To investigate the features of ERP-P300 in different stages of VCI and provide objective foundations for the early diagnosis of VCI. Methods: Fifty patients with VaD and 50 patients with VCIND were selected according to diagnostic standard of VCI,and ischemic cerebrovascular disease patients with normal cognition as a control group. Auditory ERP-P300 were studied separately. Results: (1)Compared with VCIND and control group,the latencies of N200,P300 and intervals of P200-N200,N200-P300 were obviously prolonged in VaD group. Compared with the control group,the latency of P300 and interval of N200-P300 in VCIND group were prolonged,the differences had statistical significance(P < 0.01).(2)In all patients the latencies of N200 and P300 had no correlation with sex,but had a negative correlation with a cognitixe assessment-MMSE score,the latency of P300 had a positive correlation with age. Conclusion: The features of ERP-P300 in VCIND are prolonged latency of P300 and the intervals of N200-P300,and reduced amplitude of P300. In VaD the latency of N200 and the intervals of P200-N200 are prolonged excluded the character of VCIND. ERP-P300 has a diagnosis value for VCI patients.