短方案超促排卵中过早黄素化与IVF结局的关系

目的:研究短方案超促排卵过程中过早黄素化对IVF结局的影响。方法:回顾性分析299个促排卵周期。结果:孕酮(P)水平随促排卵的进程呈上升趋势,在hCG注射后d1达峰值;P水平与E2和卵子数目有关,与LH无明显相关;当hCG注射日P>1.6 ng/ml时,临床妊娠率显著下降[40.4% vs 54.5%(P≤1.6 ng/ml)],而且随着P的进一步升高,临床妊娠率进一步下降;P升高并未影响受精率、优质胚胎率和胚胎数量。结论:P>1.6ng/ml提示了过早黄素化的出现,预示了临床妊娠率降低。

Relationship Between Premature Luteinization and Outcome of IVF in Short-term Protocol

Objective: To gain insight into the relationship between premature luteinization and outcome of IVF in short-term protocol. Methods: 299 short-term protocol were studied. Results: Serum progesterone level displayed an ascending trend in the cycles and reached peak level on the first day after hCG administration. Serum P level had a relationship with serum estrogen level and the number of follicles, but not with serum LH level. When serum P level>1.6 ng/ml on the day of hCG administration, the clinical pregnancy rate statistically decreased as compared with serum P level≤1.6 ng/ml (40.4% : 54.5%), and with the further rising of P, clinical pregnancy rate further declined. The level of P did not affect fertility rate, the rate of good quality embryo and the number of available embryos. Conclusion: Serum P level>1.6ng/ml predicted the premature luteinization and low clinical pregnancy rate.