| 维A类化合物4-APR抑制肿瘤侵袭、转移的作用 |
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| 引用本文： | 施波,李兰敏,尤胜权,徐世平,韩锐. 维A类化合物4-APR抑制肿瘤侵袭、转移的作用[J]. 药学学报, 1997, 32(1): 33-37 |
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| 作者姓名： | 施波 李兰敏 尤胜权 徐世平 韩锐 |
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| 作者单位： | 中国医学科学院，中国协和医科大学药物研究所 |
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| 摘 要： | 用体内外实验模型,研究了新维A类化合物4-乙酰胺苯基维A酸酯(4-APR)对肿瘤侵袭、转移的抑制作用。4-APR 43.3mg·kg-1po即能减少小鼠Lewis肺癌的自发性肺转移瘤数。半体内实验证明4-APR10-5mol·L-1和10-6mol·L-1对B16-F10癌细胞的人工肺转移瘤数分别抑制67.9%和36.6%。体外实验显示,4-APR对B16-F10细胞侵袭重组基底膜的抑制率分别为54.2%和41.9%。
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| 关 键 词： | 维A类化合物 4-乙酰胺苯基维A酸酯(4-APR) 抗肿瘤侵袭 抗肿瘤转移 Lewis肺癌 B16-F10黑色素瘤细胞 |
| 收稿时间： | 1995-03-20 |
INHIBITION OF TUMOR INVASION AND METASTASIS BY RETINOID 4-APR |
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| B Shi,LM Li,SQ You,SP Xu and R Han. INHIBITION OF TUMOR INVASION AND METASTASIS BY RETINOID 4-APR[J]. Acta pharmaceutica Sinica, 1997, 32(1): 33-37 |
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| Authors: | B Shi LM Li SQ You SP Xu R Han |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050. |
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| Abstract: | The anti-invasive and anti-metastatic effects with new retinoid 4-acetamidophenyl retinoate (4-APR) were studied using in vitro and in vivo experiments. 4-APR, at the dose of 43.3 mg.kg-1.day-1 p.o., was shown to reduce the spontaneous lung metastatic foci of Lewis lung carcinoma. 4-APR was also found to inhibit the artificial lung metastasis of B16-F10 cells by 67.9% and 36.6% and suppress the reconstituted basement membrane invasion of B16-F10 cells by 54.2% and 41.9% at the concentrations of 10(-5) mol.L-1 and 10(-6) mol.L-1, respectively. |
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| Keywords: | Retinoid 4 acetamidophenyl retinoate(4 APR) Anti invasion Anti metastasis Lewis lung carcinoma B16 F10 melanoma cell |
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