| 犬急性出血坏死性胰腺炎早期血浆、胰、肺组织环核苷酸的变化 |
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| 引用本文： | 顾明,王秦平,李少华. 犬急性出血坏死性胰腺炎早期血浆、胰、肺组织环核苷酸的变化[J]. 第二军医大学学报, 1986, 0(1) |
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| 作者姓名： | 顾明 王秦平 李少华 |
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| 作者单位： | 第二军医大学病理生理学教研室(顾明，王秦平)，第二军医大学病理生理学教研室(李少华) |
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| 摘 要： | 用放射竞争蛋白结合法测定了犬急性出血坏死性胰腺炎时血浆、肺及胰腺组织cAMP、cGMP含量。胰腺炎后30分钟血浆cAMP升高3倍以上,持续5小时。与对照组相比,胰腺炎动物肺组织cAMP明显增高,胰腺组织降低。血浆、肺及胰腺组织cGMP无显著变化。本文对胰腺炎后血浆、肺与胰腺组织环核苷酸变化的机理进行了讨论。
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| 关 键 词： | 胰腺炎 环-磷酸腺苷(cAMP) 环-磷酸乌嘌呤(cGMP) 血浆 肺 胰 动物疾病模型 犬 |
THE CHANGES OF CYCLIC NUCLEOTIDES IN PLASMA, PANCREAS AND LUNGS DURING EARLY PHASE OF ACUTE HEMORRHAGIC PANCREATITIS IN DOGS |
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| Gu Ming,et al. THE CHANGES OF CYCLIC NUCLEOTIDES IN PLASMA, PANCREAS AND LUNGS DURING EARLY PHASE OF ACUTE HEMORRHAGIC PANCREATITIS IN DOGS[J]. Former Academic Journal of Second Military Medical University, 1986, 0(1) |
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| Authors: | Gu Ming et al |
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| Affiliation: | Department of Pathophysiology |
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| Abstract: | Cyclic nucleotides in plasma, lung and pancreas were determined by radio-competitive protein binding assay before and after acute experimental pancreatitis in dogs. Plasma cAMP was increased three-fold 30 minutes after pancreatitis and remained at high level for 5 hours. cAMP was increased in the lungs and decreased in the pancreas,as compared with the controls.There were no significant changes for cGMP. The mechanisms of the above changes were discussed. |
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| Keywords: | pancreatitis adenosine cyclic monophosphate (cAMP) guanine cyclic monophosphate (cGMP) plasma lung pancreas |
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