3.0TMR多b值DWI序列评价胰腺癌放疗疗效

目的 应用3.0T MR多b值DWI序列评价胰腺癌放疗疗效。方法 对24例胰腺癌患者行DWI扫描,b值为0,600,800,1000 s/mm²,于AW 4.5工作站利用Functool ADC软件进行处理,记录胰腺癌肿块区、肿块邻近区、肿块远离区ADC值;放疗1个月后再重复上述操作过程;比较胰腺癌患者放疗前后各b值条件下各测量区域ADC值,计算放疗前后胰腺癌肿块区ADC值变化率(rADC)、筛选评价放疗疗效的最佳b值。结果 b值分别取600、800、1000 s/mm²时,放疗前肿块区与邻近区ADC值的差异无统计学意义(t=1.75、0.22、0.38,P均>0.05),肿块区与肿块远离区ADC值的差异有统计学意义(t=7.19、3.98、3.50,P均<0.01);肿块区、肿块邻近区放疗前后ADC值的差异均有统计学意义(肿块区:t=7.94、5.95、6.51,P均<0.01;肿块邻近区:t=2.96、6.46、8.83,P均<0.01),肿块远离区放疗前后ADC值的差异无统计学意义(t=0.53、1.99、2.02,P均 >0.05)。b值为600,800,1000 s/mm²时的rADC分别为(32.42±1.97)%、(28.44±2.44)%、(30.27±2.03)%。评价放疗疗效最佳b值为600 s/mm²。结论 3.0T MR多b值DWI序列评价胰腺癌放疗早期疗效具有重要临床意义。

3.0T MR with multi-b-value diffusion weighted imaging on evaluation of the treatment effect of radiotherapy in pancreatic cancer

Objective To explore the value of 3.0T MR with multi-b-value DWI on evaluation of the effection of radiotherapy in patients with pancreatic cancer. Methods Totally 24 patients with pancreatic cancer underwent DWI scans, with b values of 0, 600, 800, 1000 s/mm². Functool ADC software were used on AW 4.5 workstations for data processing, and the ADC value of lump zone, adjacent lump zone and away from the lump zone were recorded. The above procedures were repeated one month after radiotherapy. The ADC values under the condition of different b values and different zones were compared before and after radiotherapy in patients with pancreatic cancer, and then the change rate of ADC (rADC) were calculated to screen the best b value. Results There were no significance difference between lump zone and adjacent lump zone before radiotherapy with b values of 600, 800, 1000 s/mm², respectively (t=1.75, 0.22, 0.38, all P >0.05), but there were statistically significant differences between lump zone and away from the lump zone (t=7.19, 3.98, 3.50, all P<0.01), The differences of lump zone and adjacent lump zone were both statistically significant between before and after radiotherapy (lump zone, t=7.94, 5.95, 6.51, all P<0.01; adjacent lump zone, t=2.96, 6.46, 8.83, all P<0.01), The difference of away from the lump zone was no significant difference between before and after radiotherapy (t=0.53, 1.99, 2.02, all P >0.05). The rADC was (32.42±1.97)%, (28.44±2.44)%, (30.27±2.03)% when b values was 600, 800, 1000 s/mm², respectively. The best b value to evaluate the effect of radiotherapy was 600 s/mm². Conclusion 3.0T MR with multi-b-value DWI has important clinical significance on evaluation of the early treatment effect of radiotherapy in patients with pancreatic cancer.