The human squamous cervical carcinoma cell line, HOG-1, is responsive to steroid hormones. |
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| Authors: | J O White R N Jones J D Croxtall R P Gleeson T Krausz S Pervez A Jamil L Guida J E Beesley W P Soutter |
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| Affiliation: | Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. |
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| Abstract: | Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease. |
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