偏头痛患儿内皮素水平和经颅彩色多谱勒检测与临床关系初探

目的 探讨偏头痛患儿血浆内皮素（ET）水平和经颅彩色多谱勒（TCD）观测脑血流变化与临床之间的关系。方法 采用放射免疫直接法（RIA）对30例偏头痛患儿动态监测血浆ET，同时行TCD检测观察颅内外血流变化，并与30例正常对照组进行比较。结果 （1）偏头痛患儿发作期血浆内皮素水平明显高于对照组，且有先兆组高于无先兆组；（2）血浆内皮素水平随头痛程度的加重而升高，间欺期略高于对照组；（3）偏头痛发作期TCD检测发现双侧颈内动脉（ICA）、大脑中动脉（MCA）及基底动脉（BA）的平均血流速度（MFV）无意氏于对照组，颅内外动脉脉动指数（PI）也略低于对照组。结论 结果表明ET可能参与儿童偏头痛的病理生理过程，TCD在该症的诊断中具有一定临床应用价值。

The investigation of bloodendothelin and TCD examintion with clinical manifestation in migraine children

Objective To study the blood endothelin level and intracranial blood volume associated with clinical manifestation in children with migraine Methods The blood endothelin was determined by radioimmunoassay and the intracranial blood volume was measured with intracranial Dopple ultrasound (TCD) in 30 children with migraine 30 matched healthy children were chosen as control Results (1)The blood endothelin level was significantly elevated during the stroke of migraine and it was higher in patients with early symptoms than those without the symptom( P <0 05) (2)The blood endothelin level was increased with the severity of the disease and it was also higher during the interval of the disease compared with the control (3)The middle flow volume(MFV) in internal carotid artery(ICA), media cerebri arteria(MCA) and basilaris arteria(BA), but not in vertebralis arteria(VA),was slower in children patients with migraine than that in the control Conclusion The blood endothelin level was elevated during the stroke and the interval,which might be involved in the pathophysiological process of migraine The MFV and the blood endothelin level might be useful of diagnosis of the disease