类风湿性关节炎风寒湿痹与风湿热痹动物模型研究

本研究在大鼠胶原诱导性关节炎(CIA)的基础上给予风寒湿、风湿热刺激及葡萄球菌肠毒素B(SEB)外涂。结果显示,单纯风寒湿、风湿热不增加CIA的发病率及炎症积分,也不改变炎症关节的表面温度,但风湿热能显著提高雌性鼠炎症关节的~(99m)Tc含量。在葡萄球菌肠毒素(SEB)外涂时,风寒湿能显著增加雄性鼠的炎症积分(与单纯SEB比较),且显著提高雄性鼠的DTH反应能力(与风湿热比较);风湿热则能显著增加雌性鼠炎症关节的~(99m)Tc含量(与风寒湿比较)。在SEB外涂时,风湿热能显著增加雌性鼠的炎症关节表面温度,但风湿热与风寒湿均显著降低雄性鼠的炎症关节表面温度。

Study on Rheumatoid Arthritis of Wind-cold-dampnes Type and Wind-heat-dampness Type Bi-Syndrome

The experiment was conducted in rats with CIA on which wind - cold - dampness, wind - heat -dampness stimulation and topical rubbing of SEB were given. Results showed that, wind - cold- dampness or wind - heat - dampness alone didn't increase the incidence of CIA and integration of inflammation, nor change the surface temperature of the affected joint. However, wind -heat -dampness markedly increased the content of 99mTc of affected joint in female rats. When SEC was rubbed on the surface, wind -cold -dampness markedly increases the integration of inflammation in male rats (as compared with pure SEB). and markedly increased the DTH reaction of male rats (as compared with wind -heat- dampness) . Whereas wind - heat dampness markedly increased the content of 99mTc of affected joints in female rats ( as compared with wind - cold - dampness) when topically applied SEB. wind - heat - dampness markedly increased the surface temperature of affected joint in female rats, while wind- heat - dampness and wind - cold - dampness markedly lowered that in the male rats.