非酒精性脂肪性肝病分子机制研究进展

非酒精性脂肪性肝病(NAFLD)是一种以肝细胞脂肪变性和脂质沉积为特征,但无过量饮酒史的临床综合征。NAFLD疾病谱包括非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)、NASH相关肝纤维化和肝硬化。NAFLD的发病机制较为复杂,至今尚未完全阐明。本文就近年NAFLD分子机制研究的新进展,包括胰岛素抵抗(IR)、肝脂肪变性、氧化应激等方面作一综述。

Advances in Studies on Molecular Mechanisms of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease （NAFLD） is a clinical syndrome characterized by hepatic steatosis and fat deposition in hepatocytes in the absence of significant alcohol use. NAFLD consists of a spectrum of disorders ranging from simple fatty liver, nonalcoholic steatohepatitis （NASH） and fibrosis/cirrhosis. The mechanism of NAFLD is complicated and has not been clarified yet. This article reviewed the new progress in the study of molecular mechanisms of NAFLD in recent years, including insulin resistance （IR）, hepatic steatosis, and oxidative stress.