Histiocytic erythema multiforme |
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| Authors: | Anita Sebastian Connor Patterson rea L Zaenglein Michael D Ioffreda Klaus F Helm |
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| Institution: | Department of Pathology, Hahnemann University Hospital/Drexel College of Medicine, Philadelphia, PA,;Department of Dermatology, Penn State Milton S. Hershey Medical Center/College of Medicine, Hershey, PA, USA, and;Department of Pathology, Penn State Milton S. Hershey Medical Center/College of Medicine, Hershey, PA, USA |
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| Abstract: | Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme. |
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