海岛居民Hs-CRP水平与心血管病危险因素关系

目的 了解海岛居民血清高敏 C反应蛋白(Hs-CRP)水平与心血管疾病危险因素的关系,为心血管病的预防控制提供参考依据。方法 采用随机分层抽样方法对在辽宁省大连市长海县抽取的395名≥30岁常住居民进行问卷调查、体格检查和血液生化学检查。结果 海岛居民血清Hs-CRP P₅、P₁₀、P₂₅、P₅₀、P₇₅、P₉₀、P₉₅水平分别为0.01、0.02、0.05、0.11、0.24、0.43、0.83 mg/L;不同特征居民比较,不同年龄、居住年限、是否患高血压和是否有心血管病史居民Hs-CRP分布间差异均有统计学意义(P<0.05);海岛居民血清ln(Hs-CRP)与年龄(r=0.26)、体质指数(r=0.32)、腰围(r=0.30)、胆固醇(r=0.18)、甘油三酯(r=0.28)、低密度脂蛋白胆固醇(r=0.21)、空腹血糖(r=0.29)、血肌酐(r=0.11)、血尿酸(r=0.21)均呈正相关(P<0.05),与高密度脂蛋白胆固醇呈负相关(r=-0.11,P<0.05);多元线性回归分析结果表明,在调整其他因素后,年龄、体质指数、空腹血糖、高密度脂蛋白胆固醇、胆固醇和吸烟是海岛居民血清Hs-CRP水平的主要影响因素。结论 海岛居民的Hs-CRP水平受年龄、体质指数、空腹血糖、高密度脂蛋白胆固醇、胆固醇和吸烟的影响;控制体重、减少肥胖有利于维持血清Hs-CRP在正常范围内。

Associations of plasma high-sensitivity C-reactive protein with traditional cardiovascular risk factors among island residents in Dalian city

Objective To investigate the relationship between plasma high-sensitivity C-reactive protein(Hs-CRP) and traditional cardiovascular risk factors in the island residents.Methods Totally 395residents of Changhai county,Dalian city,were selected for the survey.We assessed the relationship between Hs-CRP and cardiovascular risk factors,such as age,blood pressure,smoking status and serum lipids.The data were analyzed with SPSS 16.0 statistical package.Results Plasma Hs-CRP level was 0.11 mg/l in the subjects.Plasma Hs-CRP positively correlated with age,waist circumference,body mass index,fasting blood glucose,cholesterol,triglycerides,low-density lipoprotein cholesterol,creatinine,and uric acid,with the correlation coefficients of 0.26,0.32,0.30,0.18,0.28,0.21,0.29,0.11,0.21,and 0.21,respectively.The high-density lipoprotein cholesterol and Hs-CRP showed a inverse correlation.In multiple regression analyses,fasting blood glucose,body mass index,age,high-density lipoprotein cholesterol,serum cholesterol,and smoking showed independent correlation with plasma Hs-CRP.Conclusion Hs-CRP level is affected by body mass index,age,fasting blood glucose,and high-density lipoprotein cholesterol and smoking status in the island residents.Weight control,reducing obesity could maintain the serum Hs-CRP within the normal level.