Telomere length,c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome |
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Authors: | Antonella Poloni Federica Serrani Eleonora Berardinelli Giulia MauriziMarianna Mariani Benedetta CostantiniSilvia Trappolini Stefania ManciniAttilio Olivieri Pietro Leoni |
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Institution: | Clinica di Ematologia, Dipartimento Scienze Cliniche e Molecolari, Ancona, Italy |
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Abstract: | Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n = 109), AML (n = 47) and in controls (n = 24). TL was lower in MDS patients than in controls (p < 0.001) and higher in L-MDS (low, intermediate-1 IPSS, p < 0.01) respect H-MDS (high, intermediate-2 IPSS, p < 0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p < 0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system. |
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