静滴多巴胺用药浓度对新生儿局部皮肤的影响

目的:研究新生儿静脉应用多巴胺时不同的药物浓度对局部皮肤不良反应的影响,为新生儿临床应用该药的防护提供依据。方法:将57例入住重症监护病房的新生儿,按照所属医疗组分为A组20例,B组20例和C组17例。分别以0.1‰(A组)、0.075‰(B组)和0.05‰(C组)的浓度静脉输入多巴胺,观察3组局部不良反应的发生情况。结果:A组20例,严重不良反应6例占30%,轻度不良反应12例占60%;B组20例,严重不良反应1例占5%,轻度不良反应为9例占45%;C组17例,严重不良反应0例,轻度不良反应3例占18%。无论严重或轻度不良反应,A组显著多于B、C组;B组轻度不良反应显著多于C组;C组未出现严重不良反应。结论:新生儿静脉输注多巴胺浓度在0.05‰时,使用较安全。

The effects of concentration of vein transfusion dopamine on skin of newborn

Objective: To study the adverse effects of different fluid concentration dopamine on newborns'skin when who have accepted vein transfusion.To provide proper suggestion for clinical application.Methods: 57 newborns who had lived in the intensive care unit were divided into A group(20 cases),B group(20 cases) and C group(17cases) according to their clinical adscription.0.1‰ dopamine,0.075‰ dopamine and 0.05‰ dopamine were used in these 3 groups respectively,and then the adverse effects of newborns'skin were observed.Results: The incidence rate of serious adverse effects of newborns'skin in the A,B and C group was 30%,5% and 0 rospectively.In general,the incidence rate of adverse effects in A group was significant higher than that of in B and C group,and the incidence rate of adverse effects in B group was significant higher than that of in C group.Conclusion: 0.05‰ dopamine for vein transfusion is proper for newborns who have in the intensive care unit,which can guarantee the safety for them.