| 肾透明细胞癌组织中AKT／mTOR的表达变化及意义 |
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| 引用本文： | 王运起,白进良.肾透明细胞癌组织中AKT／mTOR的表达变化及意义[J].山东医药,2009,49(46):7-8. |
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| 作者姓名： | 王运起 白进良 |
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| 作者单位： | 兰州大学第一医院,兰州,730030 |
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| 摘 要： | 目的观察磷酸化蛋白激酶B（p-AKT）和磷酸化哺乳动物雷帕霉素靶蛋白（p-mTOR）因子在肾透明细胞癌组织中的表达变化，为mTOR及AKT抑制剂应用于肾透明细胞癌的治疗提供依据。方法用免疫组化染色测定肾透明细胞癌和正常肾组织中p-AKT和p-mTOR的表达情况。结果p-AKT在肾透明细胞癌和正常肾组织中的阳性表达率分别为61．3％、26．1％（P〈0．01），p-mTOR的阳性表达率分别为56．0％、28．3％（P〈0．05）。P—AKT表达与肿瘤临床分期明显相关，临床分期越高，其阳性表达率越高（P〈0．05）。p-mTOR蛋白表达与肿瘤临床分期也具有相关性（P〈0．05）。肾透明细胞癌组织中p-AKT与p-mTOR的表达呈正相关（r=0．953，P=0．000）。结论AKT／mTOR信号通路在肾透明细胞癌组织中被过度激活。理论上，应用mTOR及AKT抑制剂可治疗肾透明细胞癌。
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| 关 键 词： | 肾肿瘤 肾透明细胞癌 磷酸化蛋白激酶B 磷酸化哺乳动物雷帕霉素靶蛋白 |
Expression and significance of AKT/mTOR signal pathway in renal clear cell carcinoma |
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| WANG Yun-qi,BAI Jin-liang.Expression and significance of AKT/mTOR signal pathway in renal clear cell carcinoma[J].Shandong Medical Journal,2009,49(46):7-8. |
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| Authors: | WANG Yun-qi BAI Jin-liang |
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| Institution: | WANG Yun-qi,BAI Jin-liang(First Hospital of Lanzhou University,Lanzhou 730030,P.R.China) |
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| Abstract: | Objective To explore the expression of p-AKT and p-mTOR factors in clear cell carcinoma of kidney and to provide evidence for mTOR and AKT inhibitors used in renal clear cell carcinoma therapy.Method The expression of p-AKT and p-mTOR in clear cell carcinoma of kidney and normal kidney tissue were measured by immunohistochemical method.Results The level of p-AKT and p-mTOR and expression in renal clear cell carcinoma were significantly higher than that in normal kindney tissues(P<0.01and 0.05).The expressio... |
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| Keywords: | renal cell carcinoma renal clear cell carcinoma phosphorylated protein kinase B phosphorylated mammalian target of rapamycin |
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