The effect of ibuprofen on the excretion of steroid metabolites |
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Authors: | Kenneth D. Ball Michael J. Levell Marshall E. Pickup |
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Affiliation: | 1. Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, North YorkshireUK;2. Division of Steroid Endocrinology, Department of Chemical Pathology, University of Leeds, LeedsUK |
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Abstract: | An inexpensive gas Chromatographic method is described that allows simultaneous measurement in urine of androsterone (A), aetiocholanolone (E), 11-hydroxyandrosterone (11-OA), 11-hydroxyaetiocholanolone (11-OE), pregnanediol (PD), pregnanetriol (PT), tetrahydrocortisone (THE) and tetrahydrocortisol (THF). Dehydroepiandrosterone was also resolved by the column.Ibuprofen was administered to five healthy normal males at a dose used therapeutically in rheumatoid arthritis (RA). The above urinary steroids were measured weekly during a control period, during a four week period of drug treatment and for four weeks after drug treatment had ceased.The excretion of A fell to a mean of 63% of the control value (P < 0.02) and returned to the control value within two weeks. 11-OA, which showed a greater variability than A, fell to the same extent (P < 0.1). No other steroid measured showed a change that could be related to the drug. |
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Keywords: | A androsterone = 3α-hydroxy-5α-androstan-17-one E aetiocholanolone = 3α-hydroxy-5β-androstan-17-one 11OA 11-hydroxyandrosterone = 3α,l1β-dihydroxy-5α-androstan-17-one 11OE 11-hydroxyaetiocholanolone = 3α, 11β-dihydroxy-5β-androstan-17-one PD pregnanediol = 5β-pregnane-3α,20α-diol PT pregnanetriol = 5β-pregnane-3α,17α,20α-triol THE tetrahydrocortisone = 3α,17α,21-trihydroxy-5β-pregnane-11,20-dione THF tetrahydrocortisol = 3α,17α,11β, 21-tetrahydroxy-5β-pregnane-20-one DHA dehydroepiandrosterone = 3β-hydroxy-5-androsten-17-one cortisone = 17α, 21-dihydroxy-4-pregnene-3,11,20-trione cortisol= 11β,17α,21-trihydroxy-4-pregnene-3,20-dione deoxycorticosterone =21-hydroxy-4-pregnene-3,20-dione 11-deoxycortisol = 17α, 21-dihydroxy-4-pregnene-3,20-dione 4-androstenedione = 4-androstene-3, 17-dione |
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