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Estimation of treatment effect in two‐stage confirmatory oncology trials of personalized medicines |
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| Authors: | Wen Li Cong Chen Xiaoyun Li Robert A. Beckman |
| Affiliation: | 1. Biostatistics and Research Decision Sciences, Merck Research Laboratories (MRL), Merck & Co., Inc, Kenilworth, NJ, U.S.A.;2. Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, U.S.A. |
| Abstract: | |
| Keywords: | basket design bias predictive biomarker interim analysis subpopulation time‐to‐event endpoint |