Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation |
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| Authors: | Greenwood-Van Meerveld Beverley Johnson Anthony C Schulkin Jay Myers Dean A |
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| Affiliation: | Oklahoma Center for Neuroscience, Oklahoma University Health Sciences Center, Oklahoma City, 73104, USA. Beverley-Greenwood@ouhsc.edu |
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| Abstract: | This study examined the long-term effects of an acute colitis on central corticotropin-releasing factor (CRF) expression. An increase in CRF mRNA in the paraventricular nucleus of the hypothalamus (PVN) and the central nucleus of the amygdala (CeA) was observed during active colitis, and the effect in the PVN was maintained following recovery. In summary, hypothalamic gene expression of CRF persists in the PVN despite resolution of an acute colitis. |
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| Keywords: | IBS, irritable bowel syndrome IBD, inflammatory bowel disease CRF, corticotropin-releasing factor TNBS, 2,4,6-trinitrobenzenesulfonic acid MPO, myeloperoxidase CNS, central nervous system CeA, central nucleus of the amygdala HPA, hypothalamo-pituitary-adrenal PVN, paraventricular nucleus of the hypothalamus mpPVN, medial parvocellular portion of the PVN HTAB, hexadodecyl trimethyl ammonium bromide Th1, T helper cell 1 Th2, T helper cell 2 IL1β, interleukin-1 beta IL6, interleukin-6 TNFα, tumor necrosis factor alpha GI, gastrointestinal GSL, grey scale level SON, supraoptic nucleus LPS, lipopolysaccharide RPA, ribonuclease protection assay |
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