| 孕期和哺乳期轻度缺锌对仔鼠学习记忆能力的影响 |
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| 引用本文： | 余晓丹,颜崇淮,史婧奕,余晓刚,张燕萍,沈晓明.孕期和哺乳期轻度缺锌对仔鼠学习记忆能力的影响[J].临床儿科杂志,2011,29(1). |
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| 作者姓名： | 余晓丹 颜崇淮 史婧奕 余晓刚 张燕萍 沈晓明 |
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| 作者单位： | 上海交通大学医学院附属新华医院,上海市儿科医学研究所,上海市环境与儿童健康重点实验室,上海,200092 |
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| 基金项目： | 国家自然科学基金资助项目(No.30600496); 上海市环境与儿童健康重点实验室基金资助项目(No.09DZ2200900); 上海交通大学医学院自然科学基金资助项目(No.YZ1044) |
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| 摘 要： | 目的探讨孕期和哺乳期母鼠缺锌对仔鼠幼年期学习记忆能力的影响。方法怀孕1 d的孕鼠随机分为轻度缺锌组和对照组,每组3只。缺锌饲料、正常饲料含锌量分别为5 mg/kg、25 mg/kg。产后每窝随机保留4只。至21 d断乳去母鼠,每组12只仔鼠,继续饲以缺锌和正常饲料,分别于28 d及58 d以Morris水迷宫测试仔鼠的短期及长期学习记忆能力。结果学习获得实验(短期记忆)及记忆保持实验(长期记忆):对照组定位能力较好,游泳轨迹以目标象限为主;而缺锌组定位能力较差,游泳轨迹比较分散;缺锌组仔鼠找到平台的潜伏期、总游程大于对照组(P<0.01);两组游速的差异无统计学意义(P>0.05)。随着训练天数的增加,对照组上述各项记录都随着训练天数增加而变化,其中潜伏期和总游程随着训练天数增加而逐步减少,游泳速度、目标象限游程占总游程的百分比随着训练天数的增加而增加,缺锌组的变化趋势不如对照组明显。结论孕期及哺乳期母鼠轻度缺锌影响仔代生长期幼鼠短期与长期学习记忆能力。
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| 关 键 词： | 孕期和哺乳期 轻度锌缺乏 学习记忆 仔鼠 |
Effect of mild zinc deficiency during pregnancy and lactation on learning and memory in offspring rats |
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| YU Xiao-dan,YAN Chong-huai,SHI Jing-yi,YU Xiao-gang,ZHANG Yan-ping,SHEN Xiao-ming.Effect of mild zinc deficiency during pregnancy and lactation on learning and memory in offspring rats[J].The Journal of Clinical Pediatrics,2011,29(1). |
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| Authors: | YU Xiao-dan YAN Chong-huai SHI Jing-yi YU Xiao-gang ZHANG Yan-ping SHEN Xiao-ming |
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| Institution: | YU Xiao-dan,YAN Chong-huai,SHI Jing-yi,YU Xiao-gang,ZHANG Yan-ping,SHEN Xiao-ming(Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai Institute for Pediatrics Research,Shanghai Key Laboratory of Children's Environmental Health,Shanghai 200092,China) |
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| Abstract: | Objective To investigate the effect of mild zinc deficiency during pregnancy and lactation on learning and memory in offspring rats.Methods Pregnant SD rats were randomly divided into two groups on first day,mild zinc deficiency group and control group.Mild zinc deficiency group fed with mild zinc deficiency diet(zinc content 5 mg/kg),and control group fed with control diet(zinc content 25 mg/kg)during pregnancy and lactation.Each group had 3 pregnant rats.After parturition,4 offspring rats with similar wei... |
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| Keywords: | pregnancy and lactation mild zinc deficiency learning and memory offspring rat |
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