| 4种自身抗体在幼年特发性关节炎早期诊断和预后评估中的意义 |
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| 引用本文： | 曾萍,李丰,唐盈,刘海英,关启鸿,刘云锋,曾华松.4种自身抗体在幼年特发性关节炎早期诊断和预后评估中的意义[J].临床儿科杂志,2011,29(1). |
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| 作者姓名： | 曾萍 李丰 唐盈 刘海英 关启鸿 刘云锋 曾华松 |
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| 作者单位： | 广州市妇女儿童医疗中心,广州市儿童医院,广州市妇婴医院儿童过敏免疫风湿病科,广东广州,510120 |
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| 基金项目： | 国家人事部留学归国人员启动基金(No.200499); 广东省自然科学基金(No.9151026003000004); 广东省科技厅科技攻关重点项目(No.2003B30503); 广州市科技局科技攻关重大项目(No.2003Z2-E0181);广州市科技局科技攻关一般引导项目(No.2005Z1-E0104); 广州市卫生局重点项目(No.2005-Zdi-08) |
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| 摘 要： | 目的探讨免疫学指标抗角蛋白抗体(AKA)、抗环瓜氨酸肽(抗CCP)、类风湿因子(RF)-IgG、RF-IgM与各分型幼年特发性关节炎(JIA)患儿早期诊断和预后之间的关系。方法收集76名经系统治疗并坚持随访治疗至少6个月的JIA患儿,在诊断初期进行AKA、抗CCP、RF-IgG、RF-IgM等免疫指标的检测,对不同亚型和预后作阳性检出率的比较,进行敏感性、特异性、相关危险度的统计学分析,并与49例健康儿童作对照比较。结果多关节炎型组的AKA、抗CCP、RF-IgG、RF-IgM的阳性检出率与正常对照组比较差异有统计学意义,全身型、少关节型、附着点炎相关型的自身抗体阳性检出率与正常对照组差异无统计学意义。4种抗体的检测对多关节炎型组的分型敏感性依次为AKA>抗CCP,RF-IgG>RF-IgM;特异性依次为RF-IgM>AKA>RF-IgG>抗CCP。难治型JIA患儿的AKA阳性检出率与普通JIA患儿差异有统计学意义;相对危险度OR为3.514。结论 AKA、抗CCP、RF-IgG、RF-IgM在JIA不同亚型早期诊断中的作用有区别;AKA、抗CCP抗体的检测对JIA多关节炎型有较好的敏感性和特异性;AKA抗体...
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| 关 键 词： | 抗角蛋白抗体 抗环瓜氨酸肽 类风湿因子 幼年特发性关节炎 |
Early diagnostic and predictive value of antikeratin antibody,anti-cyclic citrullinated peptide antibody,and rheumatoid factors in juvenile idiopathic arthritis |
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| ZENG Ping,LI Feng,TANG ying,LIU Hai-ying,GUAN Qi-hong,LIU Yun-feng,ZENG Huang-song.Early diagnostic and predictive value of antikeratin antibody,anti-cyclic citrullinated peptide antibody,and rheumatoid factors in juvenile idiopathic arthritis[J].The Journal of Clinical Pediatrics,2011,29(1). |
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| Authors: | ZENG Ping LI Feng TANG ying LIU Hai-ying GUAN Qi-hong LIU Yun-feng ZENG Huang-song |
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| Institution: | ZENG Ping,LI Feng,TANG Ying,LIU Hai-ying,GUAN Qi-hong,LIU Yun-feng,ZENG Huang-song(Department of Allergy,Immunology and Rheumatology,Guangzhou Women and Children's Medical Center,Guangzhou Children's Hospital,Guangzhou Women and Infants' Hospital,Guangzhou 510120,Guangdong,China) |
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| Abstract: | Objective To investigate the value of antikeratin antibody(AKA),anti-cyclic citrullinated peptide antibody(anti-CCP)and rheumatoid factor(RF-IgG,RF-IgM)in early diagnosis and prediction of juvenile idiopathic arthritis(JIA).Methods Seventy-six patients with JIA were enrolled and follow-up at least 6 months.The blood samples were collected to measure AKA,anti-CCP,RF-IgG,RF-IgM upon admission.The frequency of positive AKA,anti-CCP,RF-IgG and RF-IgM in different subtype and refractoriness were compared.Forty-n... |
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| Keywords: | antikeratin antibody anti-cyclic citrullinated peptide antibody rheumatoid factor juvenile idiopathic arthritis |
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