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培哚普利联用胺碘酮在非瓣膜性房颤复律后维持窦性心律的观察
引用本文:张后民,陈明.培哚普利联用胺碘酮在非瓣膜性房颤复律后维持窦性心律的观察[J].重庆医学,2009,38(9).
作者姓名:张后民  陈明
作者单位:1. 重庆三峡医药高等专科学校第二附属医院心内科,404000
2. 重庆医科大学附属第一医院心内科,400016
摘    要:目的 评价血管紧张素转化酶抑制剂培哚普利联用胺碘酮在持续性非瓣膜性心房颤动转复后维持窦性心律的作用及对左心房功能的影响.方法 将54例持续性非瓣膜性房颤患者药物或电复律后随机分为胺碘酮组(Ⅰ组,n=26)、胺碘酮加培哚普利组(Ⅱ组,n=28),治疗随访时间为1年,比较两组治疗后的窦性心律维持率以及治疗前、治疗后6个月、12个月的左心房内径.结果 治疗12个月后,Ⅰ组左心房内径大于Ⅱ组(P<0.05).Ⅰ组窦性心律的维持率明显低于Ⅱ组(P<0.05).结论 胺碘酮联用培哚普利在持续性非瓣膜性心房颤动转复后维持窦性心律优于单用胺碘酮,并能抑制左心房的扩大.

关 键 词:心房颤动  胺碘酮  培哚普利

Clinical efficacy of perindopril combination therapy with amiodarone in patients with persistent non-valvular atrial fibrillation
ZHANG Hou-min,CHEN Ming.Clinical efficacy of perindopril combination therapy with amiodarone in patients with persistent non-valvular atrial fibrillation[J].Chongqing Medical Journal,2009,38(9).
Authors:ZHANG Hou-min  CHEN Ming
Institution:ZHANG Hou-min1,CHEN Ming2(1.Department of Cardiology,Second Affiliated Hospital of Chongqing Sanxia Medical College,Chongqing 404000,China,2.Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
Abstract:Objective To evaluate the clinical efficacy in angiotensin-converting enzyme inhibitor perindopril combination with amiodarone after the resumption of persistent non-valvular atrial fibrillation.Methods Fifty-four patients with persistent non-valvular atrial fibrillation were included in the study and randomly divided into two groups:group 1(amiodarone group,n=26)was treated with amiodarone alone,group 2(amiodarone plus perindopril group,n=28) was treated with amiodarone and perindopril in combination.The d...
Keywords:atrial fibrillation  amiodarone  perindopr  
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