| 利麻鼻用喷雾剂的制备及临床应用 |
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| 引用本文： | 梁勇,黄北雄,邓水德.利麻鼻用喷雾剂的制备及临床应用[J].中国药房,2002,13(1):23-24. |
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| 作者姓名： | 梁勇 黄北雄 邓水德 |
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| 作者单位： | 1. 广西桂东人民医院,梧州市，543001
2. 广西贺州地区药品检验所,梧州市，543001 |
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| 摘 要： | 目的 :研究制定利麻鼻用喷雾剂制备和控制方法 ,并观察其临床疗效。方法 :采用紫外分光光度法和旋光法分别测定利巴韦林和盐酸麻黄碱的含量 ,并对40例患者进行临床疗效观察。结果 :利巴韦林和盐酸麻黄碱的平均回收率分别为100 05 %(RSD=0 50 %)和100 10 %(RSD=0 29 %) ,对病毒性上呼吸道感染的有效率为97 %。结论 :利麻鼻用喷雾剂制备工艺合理 ,性质稳定 ,质控方法可行 ,疗效可靠 ,有推广应用价值。
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| 关 键 词： | 利麻鼻用喷雾剂 制备 质量控制 临床应用 |
| 文章编号： | 1001-0408(2002)01-0023-02 |
| 修稿时间： | 2001年5月14日 |
Preparation and Clinical Application of Ribavirin and Ephedrine Nasal Spray |
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| LIANG Yong.Preparation and Clinical Application of Ribavirin and Ephedrine Nasal Spray[J].China Pharmacy,2002,13(1):23-24. |
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| Authors: | LIANG Yong |
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| Abstract: | OBJECTIVE:To study the preparation and quality control methods of ribavirin and ephedrine nasal spray and observe its clinical therapeutic efficacy.METHODS:To determine the content of ribavirin and that of ephedrine hydrochloride by ultraviolet spectrophotometry and polarimetry respectively and observe the clinical therapeutic efficacy in 40 patients.RES_ULTS:The average recoveries of ribavirin and ephedrine hydrochloride were 100.05%(RSD=0.50%) and 100.10%(RSD=0.29%) respectively.Its effective rate in treating virus infections of upper respiratory tract was 97%.CONCLUSION:The preparation of ribavirin and ephedrine nasal sprays is reasonable in technology,stable in quality,feasible in quality control and reliable in therapeutic efficacy.It is worth popularizing the application of this preparation. |
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| Keywords: | ribavirin and ephedrine nasal spray preparation quality control clinical application |
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