曲安奈德玻璃体内注射治疗黄斑水肿对眼压的影响观察

目的:评价曲安奈德玻璃体内注射治疗糖尿病性黄斑水肿在眼压方面的安全性。方法:将双眼糖尿病性黄斑水肿患者分别采用4m g和8m g不同剂量的曲安奈德玻璃体内注射,观察最佳矫正视力维持时间和眼压升高情况的差异。结果:两种剂量的曲安奈德玻璃体内注射均可使黄斑水肿消退,最佳矫正视力维持时间两组有显著性差异(P<0.05),4m g和8m g两种剂量曲安奈德玻璃体内注射引起眼压升高无显著性差异(P>0.05)。结论:4m g和8m g曲安奈德玻璃体内注射均可引起眼压升高,可尝试应用8m g剂量替代4m g曲安奈德玻璃体内注射以维持最佳矫正视力和减少玻璃体内注射次数带来的风险。

The effects on intraocular pressure of intravitreal injection with 8mg Triamcinolone acetonide for treating diabetic macular edema

Objective: To evaluate the security of intraocular pressure of intravitreal injection with 8mg triamcinolone acetonide(TA) for treating diabetic macular edema(DME).Methods: Intravitreal injection with 4mg or 8mg TA for treating biocular diabetic macular edema,observe the difference between best corrected vision lasting time and the rising of intraocular pressure(IOP).Results: Intravitreal injection with TA of two different doses both reduced diabetic macular edema,the lasting time of best corrected vision had notable statistical significance compared with that before the treatment, the risen IOP caused by intravitreal injection with 4mg or 8mg TA had no statistical significance(t=0.298,P>0.05).Conclusion: Both 4mg and 8mg intravitreal injection with TA had the statistical significance of rising IOP,but the risen IOP caused by different doses of Intravitreal injection with TA had no statistical significance.It′s an attempt to use 8mg TA to replace 4mg in intravitreal injection in order to maintain the best corrected vision and reduce the risk of times of TA.