| 大肠癌组织中Ang-1、Ang-2及受体Tie-2的表达及意义 |
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| 引用本文： | 闫巍中,温春阳,张继红,王爱平,王彩芹,史忠新. 大肠癌组织中Ang-1、Ang-2及受体Tie-2的表达及意义[J]. 吉林医学, 2011, 32(13): 2501-2505 |
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| 作者姓名： | 闫巍中 温春阳 张继红 王爱平 王彩芹 史忠新 |
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| 作者单位： | 吉林省吉林市中心医院;北华大学医学部;北华大学第一临床医学院; |
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| 摘 要： | 目的:旨在研究促血管生成素-1(Ang-1)、促血管生成素-2(Ang-2)和促血管生成素受体(Tie-2)在大肠癌中的表达,分析Ang-1、Ang-2和Tie-2的表达与大肠癌的组织学分化程度的关系,探讨三者在大肠癌进展中的作用,为大肠癌的临床治疗提供新的靶点。方法:应用免疫组化SP法检测64例大肠癌组织中的Ang-1、Ang-2和Tie-2的表达;RT-PCR检测Ang-1、Ang-2和Tie-2mRNA在大肠癌组织中的的表达。结果:Ang-1、Ang-2与Tie-2在癌组织高、中、低分化程度上的表达呈现为肿瘤的分化程度越低,蛋白与RNA表达越明显(P<0.05)。结论:Ang-1、Ang-2及Tie-2的表达程度与大肠癌的进展呈正相关。
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| 关 键 词： | Ang-1 Ang-2 Tie-2 血管新生 大肠癌 |
Expression and value of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue |
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| YAN Wei-zhong,WEN Chun-yang,ZHANG Ji-hong,et al. Expression and value of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue[J]. Jilin Medical Journal, 2011, 32(13): 2501-2505 |
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| Authors: | YAN Wei-zhong WEN Chun-yang ZHANG Ji-hong et al |
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| Affiliation: | YAN Wei-zhong,WEN Chun-yang,ZHANG Ji-hong,et al(The Central Hospital of Jilin City,Jilin 132011,China) |
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| Abstract: | Objective To study the expression of Ang-1,Ang-2 and receptor Tie-2 in colorectal cancer tissue,and explore the relationship between the expression of Ang-1,Ang-2 and receptor Tie-2 with the histological differentiation degree,provide new targets for the clinical treatment of colorectal cancer.Method The expression of Ang-1,Ang-2 and receptor Tie-2 in 64 cases of colorectal cancer tissues were detected with immunohistochemistry SP method,the expression of Ang-1,Ang-2 and receptor Tie-2 mRNA in colorectal ca... |
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| Keywords: | Ang-1 Ang-2 Tie-2 Angiogenesis Colorectal cancer |
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