106例老年支气管扩张症患者感染加重期病原菌与耐药性分析

目的:了解老年支气管扩张症患者感染加重期常见病原菌及其耐药性的情况,为临床治疗提供参考。方法:分离鉴定106例老年支气管扩张症痰合格标本进行培养及药敏试验,用KB纸片法行16种抗生素的敏感性测定,对结果进行统计。结果:106例患者痰培养阳性者共95例,共获得致病细菌株95株,革兰阴性杆菌占71.7%,革兰阳性球菌占17.9%,且MRSA(+)。其中铜绿假单胞菌最多(39.6%),其次是产ESRLS肺炎克雷伯菌(13%),金黄色葡萄球菌仅占(12.3%),对亚胺培南、第三、四代头孢菌素及氟喹诺酮类抗生素敏感性较高,氨基糖苷类抗生素中阿米卡星敏感性较高,对其他药物敏感性较低。而革兰阳性菌对青霉素、红霉素几乎全部耐药,未发现对万古霉素耐药。结论:支气管扩张症患者感染加重期痰标本病原菌分布以革兰阴性菌为主,第三、四代头孢菌素及氟喹诺酮类药物可作为支气管扩张症治疗经验用药的首选,且耐药严重,临床选择抗生素时应慎重。

106 patients aged bronchiectasis patients infected bacteria and resistance to increase period

Objective Separate identification of 2005～2009 hospital respiratory medicine of 106 patients aged bronchiectasis sputum specimens from qualified and antibiotic sensitivity tests,using KB paper method of antibiotic sensitivity to do and determination,the statistics.Method Separate identification of 2005～2009 hospital respiratory medicine of 106 patients aged bronchiectasis sputum specimens from qualified and antibiotic sensitivity tests,using KB paper method of antibiotic sensitivity to do and determination,the statistics.Results 106 patients 95 cases were positive sputum cultures,pathogenic bacteria strains 95,gram-negative bacteria accounted for 71.7 respectively,gram-positive cocci accounts and 17.9 MRSA（＋）.One pseudomonas aeruginosa（39.6%）,the second is to produce ESRLS pneumonia crayresearch bacteria（13%）,staphylococcus aureus（12.3%）,only for,the third and fourth generation cephalosporin and fluorine quinolone antibacterial,high sensitivity of aminoglycoside antibiotics sensitivity in clavulanic,low sensitivity to other drugs.While gram-positive bacterium to penicillin,erythromycin resistance,almost all found to vancomycin resistance.Conclusions Bronchiectasis patients infected patients,pathogen aggravating period sputum samples in gram-negative bacterium,the third and fourth generation cephalosporin and fluorine quinolone as bronchiectasis drug treatment experience,and the first clinical drug resistance,serious when antibiotics.