Annularins A-H: new polyketide metabolites from the freshwater aquatic fungus Annulatascus triseptatus |
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| Authors: | Li Chen Nitka Meaghan V Gloer James B Campbell Jinx Shearer Carol A |
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| Affiliation: | Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA. |
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| Abstract: | Eight new polyketide metabolites, annularins A-H (1-8), along with the known compound (-)-(S)-p-hydroxyphenyllactic acid, were isolated from the organic extracts of the freshwater fungus Annulatascus triseptatus. Compounds 1-6 are 3,4,5-trisubstituted alpha-pyrones, and the fused bicyclic pyrone-furanone system in annularin F (6) has not been reported previously among natural products. Compounds 7 and 8 are 3,4-disubstituted alpha,beta-unsaturated gamma-lactones. Annularins A (1), B (2), C (3), and F (6) exhibited antibacterial activity. |
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