凉血解毒活血汤预防放射性肺炎的随机对照试验

背景：放射性肺炎是胸部肿瘤放射治疗中最常见的并发症之一,严重影响患者的生存质量,甚至威胁生命。目前尚无有效的中医或西医治疗方案预防放射性肺炎的发生。目的：观察凉血解毒活血汤预防放射性肺炎的临床疗效。设计、场所、对象和干预措施：前瞻性随机对照设计。将解放军总医院放疗科确定需要进行放射治疗的肺癌患者100例,随机分为治疗组和对照组,每组各50例。对照组单纯行放疗,治疗组在进行放疗的同时口服凉血解毒活血汤。治疗过程中治疗组脱落3例,剔除1例;对照组脱落6例,剔除2例。主要结局：比较放射性肺炎发生率,并用美国肿瘤放射治疗协作组（Radiation Therapy Oncology Group,RTOG）急性放射性损伤分级标准、临床影像生理评分系统（clinical-radiographic-physiologic score system,CRP）、身体机能状态量表（Karnofsky Performance Status Scale,KPS）进行评估。结果：放射性肺炎发生率,治疗组为13.04%,对照组为33.33%,两组比较,差异有统计学意义（P〈0.05）;按RTOG分级标准,治疗组放射性肺炎患者肺损伤程度明显低于对照组（P〈0.05）;治疗组CRP评分显著低于对照组（P〈0.05）;治疗组KPS评分显著高于对照组（P〈0.05）。结论：凉血解毒活血汤可降低肺癌放疗患者的放射性肺炎发生率,减轻急性放射性肺损害程度,并可减轻患者症状,改善患者生存质量。

Efficacy of Liangxue Jiedu Huoxue Decoction in prevention of radiation pneumonitis: a randomized controlled trial

Background:Radiation pneumonitis is one of the most common complications during radiotherapy of thoracic tumors.It impacts the quality of life of the patients and has life-threatening danger.However,there is a lack of drugs for prevention and treatment of this disease.Objective:To evaluate the efficacy of Liangxue Jiedu Huoxue Decoction,a compound traditional Chinese herbal medicine,in prevention of radiation pneumonitis.Design,setting,participants and interventions:A prospective randomized clinical study w...