| +Gz暴露对大鼠大脑皮层HSP70蛋白表达的影响 |
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| 引用本文： | 韩磊,李鸣皋,马贵喜,孙喜庆. +Gz暴露对大鼠大脑皮层HSP70蛋白表达的影响[J]. 西北国防医学杂志, 2006, 27(2): 85-86,F0003 |
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| 作者姓名： | 韩磊 李鸣皋 马贵喜 孙喜庆 |
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| 作者单位： | 1. 解放军海军总医院航空潜水医学中心,北京,100037
2. 第四军医大学航空航天医学系航空生物动力学教研室 |
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| 摘 要： | 目的：观察＋Gz暴露对大鼠大脑皮层HSP70蛋白表达水平的影响，探讨＋Gz暴露致脑损伤的机理。方法：100只SD大鼠随机分为对照组，＋2Gz暴露组，＋6Gz暴露组，＋10Gz暴露组，各组在G暴露后的6h、1、2．4、6d处死，免疫组织化学方法观察大鼠脑皮层HSP70蛋白表达情况，并对结果进行统计分析。结果：3个＋Gz暴露组的HSP70蛋白表达水平均显著高于对照组；不同G值之间的比较表明，＋6Gz组HSP70蛋白表达水平最高，＋10Gz组最低。结论：＋Gz暴露对大鼠大脑皮层HSP70蛋白表达水平有显著影响。
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| 关 键 词： | HSP70蛋白 Gz暴露 大鼠 |
| 文章编号： | 1007-8622（2006）02-0085-02 |
| 收稿时间： | 2005-12-20 |
| 修稿时间： | 2005-12-20 |
Effect of +Gz exposures on the expression of HSP70 protein in rat cortex |
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| HAN Lei, LI Ming-gao, MA Gui-xi. Effect of +Gz exposures on the expression of HSP70 protein in rat cortex[J]. Medical Journal of National Defending Forces in Northwest China, 2006, 27(2): 85-86,F0003 |
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| Authors: | HAN Lei LI Ming-gao MA Gui-xi |
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| Abstract: | Objective:To observe the changes of expression level of HSP70 protein in rat cortex after exposure to(+ Gz) and investigate the mechanism of brain injury induced by +Gz exposure.Methods: A total of 100 rats were divided into 4 groups: control group,+2 Gz group,+6 Gz group and +10 Gz group.The rats were killed at 6 h,1 d,2 d,4 d and 6 d after exposure and the changes of HSP70 protein expression level were measured with immunohistochemical technology.Results:The HSP70 protein expression level of +Gz exposure groups were significantly higher than that of control group.The highest expression level was in +6 Gz group and the lowest was in +10 Gz group.Conclusion:Effect of +Gz exposures on the expression of HSP70 protein in rat cortex is significant. |
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| Keywords: | HSP70 potein +Gz exposure Rat |
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