E-钙黏附素、自分泌运动因子受体在乳腺癌中的表达

目的了解E-钙黏附素（E-CD）、自分泌运动因子受体（AMFR）在乳腺癌组织中的表达状况及临床病理意义。方法应用免疫组化SABC方法研究101例乳腺浸润性导管癌组织E—CD、AMFR的表达。结果乳腺浸润性导管癌E-CD表达明显下调，组织学Ⅰ、Ⅱ、Ⅲ级组相比，差异有显著性（P〈0．05），E-CD表达随级别增高而减弱。E-CD表达水平与淋巴结是否转移相关（P〈0．05）。与正常乳腺组织相比，浸润性导管癌AMFR明显高表达，表达水平与乳腺癌组织学分化差、TNM分期有关（P〈0．05）。E-CD与AMFR表达强度呈负相关（P〈0．05）。结论乳腺浸润性导管癌同时存在E-CD表达下调和AMFR表达上调，联合运用这两项标记对于估计乳腺癌的生物学特性具有重要价值。

Significance of the expressions of E-cadherin and autocrine motility factor receptor in breast carcinomas

Objective To investigate the expressions of autocrine motility factor receptor (AMFR)and E-cadherin(E-CD) in breast carcinomas and assess their clinicopathologic characteristics. Methods The expressions of AMFR were determined in 101 cases of primary breast cancer using immunohistochemical SABC method.Reults The expression of E-CD was significantly downregulated in invasive ductal carcinoma. Positive expression of E-CD correlated significantly with histologic grade and lymph node metastasis(P<0.05),with decreasing level from grade1 to grade 3. Compared with normal breast tissues, AMFR was higher in breast carcinaomas, which was significantly associated with poor tumor differentiation and TNM stage(P<0.05). An inverse correlation was found between E-CD and AMFR expressions(P<0.05). Conclusion Downregulated E-CD and upregulated AMFR express simultaneously in invasive ductal carcinoma. Dual use of these two markers may be useful to evaluate the biologic potential of breast carcinomas.