| 依布利特对兔左心室肌细胞钠离子通道跨壁异质性的影响 |
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| 引用本文： | 孙家安,王洁,齐书英,彭育红,丁超,何振山,李俊峡.依布利特对兔左心室肌细胞钠离子通道跨壁异质性的影响[J].华北国防医药,2010,22(1). |
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| 作者姓名： | 孙家安 王洁 齐书英 彭育红 丁超 何振山 李俊峡 |
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| 作者单位： | 解放军白求恩国际和平医院心血管内科;北京市三博医院ICU; |
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| 摘 要： | 目的探讨依布利特抗室性心律失常作用的离子机制。方法利用酶解的方法分离出新西兰纯种大耳白兔(体重2.0～2.5kg)心外膜、心内膜和中层心室肌细胞。将各层细胞按处理试剂分为正常对照组、依布利特A(10-7mol/L)组、依布利特B(10-6mol/L)组。应用膜片钳全细胞记录方法,记录各层心室肌细胞钠通道电流(INa)活性的变化,并与正常对照组心肌细胞进行比较分析。结果3组间的中层心肌细胞INa电流I-V曲线差异有统计学意义(P<0.05);对照组与依布利特组的心内膜下细胞INaI-V差异有统计学意义(P<0.01),依布利特A、B组间无显著差异(P>0.05);对照组与依布利特两组心外膜下细胞INaI-V差异有统计学意义(P<0.05),依布利特A、B组间无差异(P>0.05)。依布利特两组与对照组中层心室肌细胞ⅠNa稳态失活曲线比较差异有统计学意义(P<0.05),依布利特A、B组间无显著差异(P>0.05);3组间心内膜下细胞ⅠNa稳态失活曲线差异有统计学意义(P<0.05);对照组与依布利特两组间的心外膜下细胞ⅠNa稳态失活曲线差异有统计学意义(P<0.01),依布利特两组间无显著差异(P>0.05)。...
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| 关 键 词： | 抗心律失常药 依布利特 兔 心肌 左心室 钠通道 |
Effects of Ibutilide on INa Current Heterogeneity in Isolated Left Ventricular Myocytes in Rabbits |
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| SUN Jia-an,WANG Jie,QI Shu-ying,PENG Yu-hong,DING Chao,HE Zhen-shan,LI Jun-xia.Effects of Ibutilide on INa Current Heterogeneity in Isolated Left Ventricular Myocytes in Rabbits[J].Medical Journal of Beijing Military Region,2010,22(1). |
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| Authors: | SUN Jia-an WANG Jie QI Shu-ying PENG Yu-hong DING Chao HE Zhen-shan LI Jun-xia |
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| Institution: | 1.Bethune International Peace Hospital of PLA;Shijiazhuang 050082;China;2.Intensive Care Unit;Beijing Sanbo Hospital;Beijing 100010;China |
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| Abstract: | Objective To explore the mechnisms of Ibutilide in ventricular arrhythmias by studying Ibulide effect on INa heterogeneity of three types of ventricular myocytes.Methods Healthy Newzealand white rabbits weighing 2.0 to 2.5 kg were selected.The three types of myocytes were isolated enzymologically from the left ventricular wall.The INa in epicardial,endocardial and midmyocardial cells were recorded by patch clamp techniques in the whole-cell configuration from the three cellular subtypes of the left ventricu... |
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| Keywords: | Anti-arrhythmia agent Ibutilide Rabbit Myocardium Left ventricle Sodium channel |
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