职业性铅接触工人氧化应激及免疫功能状况调查

  目的  探索体内不同浓度的铅负荷对男性工人氧化应激及免疫功能造成的影响。
  方法  以某蓄电池厂工人为研究对象，探讨了血铅与氧化应激及免疫功能的关系。
  结果  共纳入130名蓄电池厂男性作业人员作为研究对象，其中高铅组（血铅> 300 μg/L）34人，中铅组（200 μg/L ≤血铅≤ 300 μg/L）51人，低铅组（血铅值< 200 μg/L）45人。与低铅组比较，中铅组人群的SOD水平升高（P < 0.05），其余各组之间的MDA、SOD、GSH-Px水平差异均无统计学意义（P > 0.05）。高铅组人群TNF-α水平高于低铅组、中铅组（P < 0.05）；其余各组之间的IgG、IgA、IgM、C3、C4、IL-2水平差异均无统计学意义（P > 0.05）。3组人群中从低铅组到高铅组，ZPP的水平逐渐升高（P < 0.05）。血铅浓度和外周血TNF-α（r_s=0.213，P < 0.05）、ZPP（r_s=0.513，P < 0.01）呈正相关，其余指标与血铅浓度之间无相关性（P > 0.05）。
  结论  随着血铅浓度的升高，铅可能对机体有一定的氧化损伤和免疫损伤倾向。

Investigation on oxidative stress and immune function of occupationally lead-exposed workers

  Objective  To study the adverse effects of lead exposure on oxidative stress and immune function of male workers.  Methods  The workers in a battery factory were studied and the relationship between their blood lead and oxidative stress and immune function was evaluated.  Results  A total of 130 male workers in this battery factory were included and according to blood lead levels they were divided into 3 groups, namely high lead exposure group (blood lead > 300 μg/L, 34 workers), medium lead exposure group (200 μg/L ≤ blood lead ≤ 300 μg/L, 51 workers) and low lead exposure group (blood lead value < 200 μg/L, 45 workers). Workers in medium lead exposure group had a higher level of SOD(P < 0.05), while there were no significant difference of MDA, SOD, and GSH-Px levels among these workers(P > 0.05). TNF-α level of workers in the high lead exposure group was higher(P < 0.05), while there were no significant differences of IgG, IgA, IgM, C3, C4, and IL-2 levels among these workers(P > 0.05). ZPP level of workers gradually increased with the increment of blood lead and the differences were statistically significant (P < 0.05) among workers in 3 groups. Blood lead concentrations were significantly correlated with peripheral blood TNF-α (r_s=0.213, P < 0.05) and ZPP (r_s=0.513, P < 0.01), while the correlations between the other indicators and blood lead concentrations were not statistically significant (P > 0.05).  Conclusion  Higher blood lead concentration may have a certain adverse effect on oxidative stress and immune function among occupationally lead-exposed workers.