阻塞性睡眠呼吸暂停低通气综合征高危人群与高血压的相关性研究

目的探究阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)高危人群的常见症状同高血压之间的相互关系。方法2018-01/10随机抽取四川省成都市武侯区的8个社区,选择社区中年龄>50岁共4691名居民进行一般情况的调查和STOP-Bang问卷的发放。根据调查结果将受试者分为高血压病例组(n=1304)及未患高血压的对照组(n=2542),将OSAHS相关因素与高血压进行相关分析。STOP-Bang评分量表包括:是否大声打鼾,是否白天疲劳,同床发现睡眠呼吸暂停,身高体重及体质指数(BMI),颈围,是否高血压;前3个条目总分大于等于2分者为OSAHS高风险者。根据调查结果将受试者分为高血压病例组(n=1304)及未患高血压的对照组(n=2542),进行STOP-Bang评分量表各项条目及总得分的单因素分析,并将所有条目与高血压患病与否纳入多因素Logistic回归分析。结果本次研究共收回有效问卷3846份,应答率为82%。高血压患者中OSAHS高风险者占19.2%(215/1304),相较于对照组4.9%(125/2542),差异有统计学意义(P<0.001)。STOP-Bang评分量表各项条目的单因素分析中,大声打鼾,白天疲劳,睡眠呼吸暂停及体质指数>28 kg/m2差异均有统计学意义(P<0.05)。以罹患高血压为因变量,将大声打鼾,白天疲劳,睡眠呼吸暂停,性别为男,体质指数(BMI)>28 kg/m2,颈围>40 cm为自变量,纳入到多因素Logistic回归模型中,结果显示呼吸暂停及体质指数(BMI)>28 kg/m2差异有统计学意义(P<0.05)。结论阻塞性睡眠呼吸暂停低通气综合征高危人群中高血压的患病率较高,肥胖是导致其患高血压的主要危险因素。

Association Study Between High Risk Population of Obstructive Sleep Apnea Hypopnea Syndrome and Hypertension

Objective To investigate the correlation between the common symptoms of the high-risk groups of obstructive sleep apnea hypopnea syndrome(OSAHS)and the prevalence of hypertension.Methods From January,2018 to October,2018,we randomly selected 8 communities in Wuhou District,Chengdu City,Sichuan Province,and selected 4691 residents aged>50 years in these communities to conduct general surveys and STOP-Bang questionnaire.According to the results of the survey,the subjects were divided into a hypertensive case group(n=1304)and a control group without hypertension(n=2542).All items and hypertension were included in multivariate logistic regression analysis.Results A total of 3846 valid questionnaires were retrieved in this study,with a response rate of 82%.The high risk of OSAHS in hypertensive patients accounted for 19.2%(215/1304),which was statistically significant(P<0.001)compared with 4.9%(125/2542)in the control group.In the univariate analysis of the items in the STOP-Bang questionnaire,there was statistically significant difference in loud snoring,daytime fatigue,sleep apnea and body mass index>28 kg/m2(P<0.05).Taking hypertension as dependent variable,loud snoring,daytime fatigue,sleep apnea,male,body mass index(BMI)>28 kg/m2,neck circumference>40 cm as independent variable,included in multivariate logistic regression model.The results showed that the difference in apnea and body mass index(BMI)>28 kg/m2 was statistically significant(P<0.05).Conclusion The prevalence of hypertension is high in people at high risk of obstructive sleep apnea hypopnea syndrome.Obesity is the main risk factor for their hypertension.