柴胡龙骨牡蛎汤加减治疗冠状动脉粥样硬化性心脏病并发抑郁焦虑患者的临床疗效分析

目的:分析柴胡龙骨牡蛎汤加减治疗冠状动脉粥样硬化性心脏病(简称冠心病)并发抑郁焦虑患者的临床疗效。方法:随机将80例冠心病并发抑郁焦虑患者分为对照组和观察组,两组均为40例,所有患者均为2017年2月-2019年2月在我院接受治疗的患者。其中对照组患者给予冠心病常规治疗,观察组患者在常规冠心病的治疗基础上加用柴胡龙骨牡蛎汤加减治疗。对比两组患者的治疗效果。结果:观察组患者的汉密顿抑郁量表(Hamilton Depression Scale,HAMD)、汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评分明显优于对照组患者(P<0.05);观察组患者的西雅图心绞痛量表(SeattleAngina Questionnaiire,SAQ)各项评分均优于对照组患者,差异显著(P<0.05);观察组患者的心绞痛治疗有效率明显高于对照组患者(P<0.05);治疗后观察组患者的总胆固醇(Total Cholesterol,TC)及低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol,LDL-C)水平明显低于对照组患者(P<0.05),而两组患者的血清甘油三酯(Triglyceride,TG)及高密度脂蛋白胆固醇(High Density Lipoprotein Cholesterol,HDL-C)水平的改善结果并无显著差异(P>0.05);且治疗后观察组患者的纤维蛋白原(Fibrinogen,FIB)与C反应蛋白(C-reactive Protein,CRP)水平均明显低于对照组患者(P<0.05);观察组患者在治疗后的中医证候积分也显著低于对照组患者(P<0.05)。结论:柴胡龙骨牡蛎汤加减治疗冠心病并发抑郁焦虑疾病具有确切的临床疗效,可有效改善患者的临床症状及负面情绪,提高其各项机体指标,同时降低其血脂水平,对其生活质量的改善具有重要的意义。

Efficacy of the Chaihu Longgu Muli decoction on coronary heart disease plus depression and anxiety

Objective:To analyze the clinical efficacy of the Chaihu Longgu Muli decoction(柴胡龙骨牡蛎汤)on coronary heart disease with depression and anxiety.Methods:80 patients were randomly divided into the control group and the observation group.Both groups included 40 patients.Patients in the control group were given conventional treatment,and patients in the observation group were treated with the Chaihu Longgu Muli decoction more.Results:The Hamilton Depression Scale and Hamilton Anxiety Scale scores in the observation group were significantly better than those in the control group(P<0.05).The scores of the Seattle Angina Questionnaiire scale were better than the control group(P<0.05).The total efficiency in the observation group was significantly higher than that in the control group(P<0.05).Indexes in the observation group were better than those in the control group(P<0.05).Conclusion:The Chaihu Longgu Muli decoction was effective on coronary heart disease with depression and anxiety.It can effectively improve the clinical symptoms and negative emotions of patients,improve their physical indicators,and reduce their blood lipid levels.