| 左金丸干预大鼠胃热证的~1H-NMR代谢组学研究 |
| |
| 引用本文： | 张璐,巫圣乾,王淑美,梁生旺,邹忠杰,龚梦鹃.左金丸干预大鼠胃热证的~1H-NMR代谢组学研究[J].中药新药与临床药理,2020(1):80-84. |
| |
| 作者姓名： | 张璐 巫圣乾 王淑美 梁生旺 邹忠杰 龚梦鹃 |
| |
| 作者单位： | 广东药科大学中药学院 |
| |
| 基金项目： | 国家自然科学基金青年基金项目（81603397,81403075） |
| |
| 摘 要： | 目的运用核磁共振氢谱(1H-NMR)代谢组学方法探讨左金丸干预大鼠胃热证的作用机制。方法采用辣椒煎液和无水乙醇灌胃建立大鼠胃热证模型。利用1H-NMR技术建立大鼠胃组织的代谢物谱图,分析左金丸(3.5 g·kg^-1)干预胃热证模型大鼠后,相关潜在生物标志物的变化。结果左金丸能对胃热证大鼠代谢紊乱产生有效的干预,并对8个与胃热证相关潜在生物标志物产生显著回调。结论左金丸干预胃热证的机制可能与调节能量代谢、氧化应激和炎症反应有关。
|
| 关 键 词： | 左金丸 胃热证 代谢组学 核磁共振氢谱 能量代谢 氧化应激 炎症反应 |
Metabonomic Studies on the Intervention Effects of Zuojin Wan in Rats with Stomach Heat Syndrome Based on ~1H-NMR |
| |
| ZHANG Lu,WU Shengqian,WANG Shumei,LIANG Shengwang,ZOU Zhongjie,GONG Mengjuan.Metabonomic Studies on the Intervention Effects of Zuojin Wan in Rats with Stomach Heat Syndrome Based on ~1H-NMR[J].Traditional Chinese Drug Research & Clinical Pharmacology,2020(1):80-84. |
| |
| Authors: | ZHANG Lu WU Shengqian WANG Shumei LIANG Shengwang ZOU Zhongjie GONG Mengjuan |
| |
| Institution: | (School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM,Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province,Guangzhou 510006 Guangdong,China) |
| |
| Abstract: | Objective To classify the mechanism of Zuojin wan(ZJW) in the intervention of stomach heat syndrome(SH) by 1 H-NMR.Methods The SH models were established by gavage of decoction of pepper and absolute ethanol in rats.A proton nuclear magnetic resonance(1 H-NMR) based metabonomic approach was developed to profile SHrelated metabolic perturbation in stomach and to investigate the intervention effect of ZJW(3.5 g·kg^-1) in rats.Results The disturbed metabolic state associated with SH in rat could be restored by ZJW.Meanwhile,eight potential biomarkers related to SH in stomach were significantly reversed by administration of ZJW.Conclusion The current study demonstrated that ZJW exerted protective effect against SH in rats,the intervention effect of ZJW on SH may be relevant to the regulation of energy metabolism,oxidative stress and inflammatory response. |
| |
| Keywords: | Zuojin wan stomach heat syndrome metabonomics 1H-NMR energy metabolism oxidative stress inflammatory response |
| 本文献已被 CNKI 维普 等数据库收录！ |
