清热化瘀方干预对急性冠脉综合征PCI术后患者炎症反应的影响

目的观察清热化瘀方对热毒痰瘀型急性冠脉综合征(ACS)患者PCI术后炎症反应的临床疗效及其安全性。方法将80例接受PCI术且中医辨证为热毒痰瘀证的ACS患者,随机分为对照组和治疗组各40例。两组均给予西医标准化治疗,治疗组在此基础上加用清热化瘀方,连续用药1个月。观察PCI术后24 h和30 d的中医证候积分;术后24 h、7 d及30 d的白细胞计数(WBC)、中性粒细胞计数(NEU)、C反应蛋白(CRP)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、超氧化物歧化酶(SOD)。结果治疗组总有效率高于对照组(P<0.05)。两组治疗后WBC、NEU明显下降(P<0.05),但差异无统计学意义(P>0.05)。两组术后30 d,CRP、hs-CRP、IL-6明显下降(P<0.05);治疗组术后7 d、30 d hs-CRP较对照组下降,7 d IL-6较对照组减少(P<0.05)。结论清热化瘀方能够明显改善急性冠脉综合征PCI术后患者中医临床症状及炎症反应,且安全性好。

Effect of Qingre Huayu Decoction on Inflammatory Response in Patients with Acute Coronary Syndrome after PCI

Objective:To observe the clinical efficacy and safety of Qingre Huayu Decoction on inflammatory reaction of patients with acute coronary syndrome(ACS)of heat toxin and phlegm stasis type after PCI.Methods:80 patients were randomly divided into the control group and the treatment group,40 cases in each.Both were treated with standard western medicine,and the treatment group was added Qingre Huayu Decoction for one month.The scores of TCM clinical symptoms of 24 hours and 30 days after PCI,WBC,NEU,CRP,hs-CRP,IL-6 and SOD after 24 hours,7 days and 30 days after PCI were observed.Results:The total effective rate of the treatment group is obviously higher than that of the control group(P<0.05).After these therapies,the WBC and the NEU were reduced remarkably in two groups(P<0.05).However,there were no significance differences in two groups(P>0.05).In the 30 days after PCI,CRP,hs-CRP and IL-6 in two groups were decreased(P<0.05).Compared with the control group,some indices in the treatment group were reduced including the hs-CRP in the 7 days and 30 days after PCI and the IL-6 in the 7 days after PCI(P<0.05).Conclusion:Qingre Huayu Decoction can significantly improve the clinical symptoms and inflammatory reaction of patients with acute coronary syndrome after PCI,and it is safe.