| 调q激光治疗黄褐斑鼠模型的病理实验研究 |
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| 引用本文： | 甘小艳,胡婷婷,蒋甜甜,冯浩. 调q激光治疗黄褐斑鼠模型的病理实验研究[J]. 临床医药实践, 2020, 0(1): 28-29,60 |
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| 作者姓名： | 甘小艳 胡婷婷 蒋甜甜 冯浩 |
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| 作者单位： | ;1.永州市中心医院;2.湖南师范大学附属第一医院湖南省人民医院 |
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| 基金项目： | 永州市科技创新及应用研究项目（项目编号：永财企指[2016]26号） |
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| 摘 要： | 目的:研究调q激光治疗户外紫外线(UVB)诱导的黄褐斑豚鼠模型的效果及可能机制。方法:选取UVB诱导的黄褐斑模型豚鼠20只,随机分为实验组(调q激光治疗组)和对照组(氢醌治疗组),每组各10只。实验组予以调q激光治疗,对照组给予氢醌治疗。4个月后观察各组豚鼠皮损变化及皮损组织病理改变。结果:实验组与对照组相比,皮损肉眼观及组织病理免疫组化表现均明显改善。结论:调q激光治疗黄褐斑豚鼠疗效显著,可能与调q激光选择性破坏黑素细胞、减少黑色素生成有关。
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| 关 键 词： | 黄褐斑 调Q激光 模型鼠 |
A pathological experimental study of q-switched laser in the treatment for chloasma mouse model induced by UVB |
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| GAN Xiaoyan,HU Tingting,JIANG Tiantian,FENG Hao. A pathological experimental study of q-switched laser in the treatment for chloasma mouse model induced by UVB[J]. Proceeding of Clinical Medicine, 2020, 0(1): 28-29,60 |
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| Authors: | GAN Xiaoyan HU Tingting JIANG Tiantian FENG Hao |
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| Affiliation: | (Yongzhou Central Hospital,Yongzhou 425000,China;Hunan Provincial People's Hospital,Changsha 410005,China) |
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| Abstract: | Objective:To explore the effect and the possible mechanism of q-switched Laser in the treatment for melasma mouse model induced by UVB.Methods:All 20 mice with chloasma induced by UVB were randomly divided into two groups:treatment group(q-switched laser therapy),the control group(hydroquinone therapy).The changes of skin lesions and pathological changes of skin lesions in each group were observed after 4 months.Results:The skin lesion performances and the histopathological manifestations of skin lesions of mice in treatment group was improved than that of control group B.Conclusion:The curative effect of q-switched Laser in melasma mouse model was significantly,which may be related to the selective destruction of q-switched Laser for melanocyte. |
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| Keywords: | chloasma q-switched laser mouse model |
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