组织多肽特异性抗原和癌胚抗原在肺癌诊断中价值

目的探讨组织多肽特异性抗原(TPS)及癌胚抗原(CEA)对肺癌诊断的临床价值.方法用化学免疫荧光法测定38例肺癌及40例良性疾病患者血中TPS水平,同时用微粒子酶免分析法测定CEA水平.结果肺癌组血中TPS、CEA水平均明显高于良性病变组(P＜0.01).TPS的敏感性为81.6%、特异性为75.0%;CEA的敏感性为42.1%、特异性为92.5%.两者联合测定敏感性为87.5%、特异性为100%.结论TPS作为肺癌的标志物敏感性高,CEA特异性强.TPS与CEA联合检测对肺癌诊断有很高的特异性,对肺癌的诊断有较大的价值.

The clinical diagnostic value of TPS and CEA in lung cancer

Objective To explore the clinical diagnostic value of tissue ploypeptide specific antigen(TPS)and carcinoembryonic antigen(CEA)in lung cancer. Methods In20patients with lung cancer and16patients with benign disease,TPS was determined by chemical immunofluorescence and CEA was determined by microaggregate enzyme immunoassay. Results 1.The serum levels of TPS and CEA were significantly higher in the patients with lung cancer than those with benign disease(p<0.01).2.In the diagnosis of lung caner,the sensitivity of TPS and CEA was81.6%,42.1%and the specificity was75.0%,92.5%respectively,moreover,the sensitivity was87.5%and the specificity was100%in combined detection of TPS and CEA. Conclusion The sensitivity of TPS was higher than that of CEA as a marker of lung caner,While the specificity of CEA was much higher than that of TPS.The combined detection of TPS and CEA may improve the sensitivity and specificity in the diagnosis of lung cancer.