| 虎力散胶囊的质量标准研究 |
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| 引用本文： | 凌志敏,李娟,曾翠梅,郭英球.虎力散胶囊的质量标准研究[J].中医药导报,2009,15(4). |
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| 作者姓名： | 凌志敏 李娟 曾翠梅 郭英球 |
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| 作者单位： | 1. 广州中医药大学第三附属医院,广东,广州,510360
2. 湖南医药工业研究所,湖南,长沙,410014 |
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| 摘 要： | 目的:建立控制虎力散胶囊的质量标准.方法:采用TLC法对虎力散胶囊中三七进行定性鉴别;采用酸碱滴定法对方中的总生物碱进行含量测定;采用HPLC法对方中三七皂苷R1与人参皂苷Rg1进行定量分析.色谱柱为C18柱(200 mmx4.6mm,5 靘),流动相为乙腈-0.05%的磷酸溶液(20:80),流速1.0mL/min.结果:薄层斑点清晰,阴性对照无干扰;三七皂苷R1与人参皂苷Rg1对照品分别在0.4036-4.036靏.1.0012-10.012靏范围内,进样量与峰面积呈良好线性关系,平均加样回收率分别为98.50%与98.62%,RSD%分别为0.79%与0.80%(n=6).结论:方法简便可行,结果准确可靠,重现性好,可作为本产品的质量控制方法.
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| 关 键 词： | 虎力散胶囊 质量标准 三七皂苷R1 人参皂苷Rg1 |
Study on the Quality standard of Hulisan Capsule |
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| LIN Zhi-min,LI Juan,ZEN Cui-mei,GUO Ying-qiu.Study on the Quality standard of Hulisan Capsule[J].GUIDING JOURNAL OF TCM,2009,15(4). |
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| Authors: | LIN Zhi-min LI Juan ZEN Cui-mei GUO Ying-qiu |
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| Institution: | LIN Zhi-min1,LI Juan2,ZEN Cui-mei1,GUO Ying-qiu2 1.The Third Affiliated Hospital to Guangzhou University of Traditional Chinese Medicine,Guangzhou,China,510360,2.Hunan Institute of Pharmaceutical Industry,Changsha,410014 |
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| Abstract: | Objective:To establish the quality standard of Hulisan Capsule.Methods:Panax notoginseng were identified by TLC. The content of total alkaloids were determined and calculated by acid-base titration based on the amounts of hydrochloric acid that reacted with alkaloid. HPLC was used to determine ginsenoside Rgl and notoginsenoside R1 contents.The separation was performed on C18 column with acetonitrile -0.05% phosphoric acid (20 :80) as a mobile phase.The flow rate was 1.0 mL/min. Results:The TLC sports devel... |
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| Keywords: | TLC HPLC |
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