| 胃肠起搏辅助抑酸药物治疗胃食管反流病疗效观察 |
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| 引用本文： | 徐丹,吴杰,王萍.胃肠起搏辅助抑酸药物治疗胃食管反流病疗效观察[J].胃肠病学和肝病学杂志,2010,19(2). |
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| 作者姓名： | 徐丹 吴杰 王萍 |
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| 作者单位： | 武汉市中心医院消化内科,湖北,武汉,430000 |
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| 摘 要： | 目的 研究胃肠起搏辅助抑酸药物治疗胃食管反流病的疗效.方法 将研究对象随机分为三组,A组24例给予埃索美拉唑镁肠溶片口服并辅助胃肠起搏器治疗,B组26例给予埃索美拉唑镁肠溶片及多潘立酮片口服,C组25例给予埃索美拉唑镁肠溶片口服,比较三组疗效及不同疗法对复发时间的影响.结果 治疗1周时,症状积分改善A组>B组>C组(P均<0.05);2周时,A组和B组差异无统计学意义,但均较C组改善更为显著;A组首次复发时间平均为(58.28±28.43)d,较B组(35.14±12.78)d和c组(19.85±7.86)d明显延长(P<0.05),B组较C组也有明显延长(P<0.05).结论 胃肠起搏辅助埃索美拉唑镁肠溶片比埃索美拉唑镁肠溶片联合多潘立酮片及单用埃索美拉唑镁肠溶片更显著地改善胃食管反流病患者的症状,且其症状缓解后的首次复发时间延长,作用持久,没有明显副作用.
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| 关 键 词： | 胃食管反流病 胃肠起搏 埃索美拉唑镁肠溶片 |
The effect of gastro-intestinal pace maker and PPI on gastroesophageal reflux disease |
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| XU Dan,WU Jie,WANG Ping.The effect of gastro-intestinal pace maker and PPI on gastroesophageal reflux disease[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(2). |
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| Authors: | XU Dan WU Jie WANG Ping |
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| Institution: | XU Dan,WU Jie,WANG Ping Department of Gastroenterology,Central Hospital of Wuhan,Wuhan 430000,China |
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| Abstract: | Objective To investigate the effect of gastro-intestinal pace maker and proton pump inhibitor (Esomeprazole Magnesium Enteric coated tablets,Nexium) on gastroesophageal reflux disease.Methods Seventy-five patients with gastroesophageal reflux disease diagnosed by Endoscopy were randomly divided into group A (gastro-intestinal pace maker and Nexium 20 mg two daily for 2 weeks),the group B (Domperidonetabiets 10 mg three daily and Nexium 20 mg two daily for 2 weeks) and the group C (Nexium 20 mg two daily for... |
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| Keywords: | Gastroesophageal reflux disease Gastro-intestinal pace maker Nexium |
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