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| 蝎毒抗海人酸诱导大鼠癫痫的作用 | |
| 引用本文： | 马飞煜,王淑英,高德红. 蝎毒抗海人酸诱导大鼠癫痫的作用[J]. 黑龙江医药科学, 2002, 25(6): 17-18 |
| 作者姓名： | 马飞煜 王淑英 高德红 |
| 作者单位： | 1. 佳木斯大学第一附属医院 2. 佳木斯大学基础医学院 3. 大庆市石油管理局龙南医院 |
| 摘 要： | 目的:研究蝎毒抗海人酸(Kainic acid KA)诱导大鼠癫痫的作用。方法:抗海人酸(10mg/kg)诱发SD大鼠出现急性癫痫发作后,将其分为2组,每天灌胃分别给予生理盐水,蝎毒粗提液(SV 100mg/kg)。10天后再次同剂量KA检测癫痫的敏感性及免疫组化测其检验结果。结果:行为学结果经统计学处理后表明,SV可明显抑制动物癫痫敏感性的形成。免疫组化结果表明, SV可防止海马硬化的形成。 |
| 关 键 词： | 蝎毒粗提液 抗癫痫敏感性 海马硬化 免疫组化 |
| 文章编号： | 1008-0104(2002)06-0017-01 |
| 修稿时间： | 2002-07-23 |
Antiepileptic effect of scorpion venom on SD rats with Epilepsy induced by kainic acid |
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| MA Feiyu WANG Shuying GAO Dehong. Antiepileptic effect of scorpion venom on SD rats with Epilepsy induced by kainic acid[J]. Heilongjiang Medicine and Pharmacy, 2002, 25(6): 17-18 | |
| Authors: | MA Feiyu WANG Shuying GAO Dehong |
| Abstract: | Objective: Antiepileptic effect of scorpion venom. Method: After epilepsy induced by convulsive dose of Kainic acid(KA, 100mg/kg) in SD rats of experiment group, the rats were divided into two groups, which treated with the saline, and scorpion venom(SV), respectively. Seizure susceptibility was examined by administerring the same dose of KA. Result: Behavior study showed that the SV could block seizure susceptibility. And immunohistochemistry results indicated it could prevent the formation of the hippocampal sclerosis. |
| Keywords: | SV epilepsy hippocampal sclerosis immunohistochemistry |
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