Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity |
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Authors: | Diana P Barraja P Lauria A Almerico A M Dattolo G Cirrincione G |
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Institution: | Dipartimento Farmacochimico Tossicologico e Biologico, Università di Palermo, Italy. |
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Abstract: | The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug. |
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