MYC amplification in two further cases of acute myeloid leukemia with trisomy 4 and double minute chromosomes |
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| Authors: | O'Malley F Rayeroux K Cole-Sinclair M Tong M Campbell L J |
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| Affiliation: | Victorian Cancer Cytogenetics Service, St. Vincent's Hospital, Victoria, Australia. |
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| Abstract: | We report two cases of trisomy 4 with double minute chromosomes (dmin): one in a woman with acute myeloid leukemia (AML), French-American-British subtype M2, the other in a man with chronic myelomonocytic leukemia. In the former case, many cells without trisomy 4 but with dmin were present, a finding not observed in previously reported cases. In both cases, fluorescence in situ hybridization studies demonstrated the double minutes to be MYC amplicons. Ten cases of AML with trisomy 4 and dmin have now been described; in the five cases investigated, the dmin have been shown to be amplified MYC gene sequences. |
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