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Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis |
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| Authors: | Sandra Braun Christoph Berg Sandra Buck Michael Gregor Reinhild Klein |
| Affiliation: | Sandra Braun, Sandra Buck, Reinhild Klein, Department of Internal Medicine II, University of Tuebingen, 72076 Tuebingen, GermanyChristoph Berg, Michael Gregor, Department of Internal Medicine I, University of Tuebingen, 72076 Tuebingen, Germany |
| Abstract: | AIM:To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC). METHODS:Sera from 95 patients with PBC were tested by enzyme-linked immunosorbent assay against 33 synthetic overlapping peptides (25 amino acids; aa) covering the entire length of the E2-subunit of PDC-E2. Furthermore,the inner lipoyl peptide 167-184 was used in an unlip oylated and a lipoylated form as well as cou... |
| Keywords: | Anti-M2 Epitope mapping E2-subunit Pyruvate dehydrogenase complex Inner lipoyl domain Active site Catalytic domain Primary biliary cirrhosis |
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| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 | |