甲型副伤寒患者血清C-反应蛋白测定的临床意义探讨

目的　探讨甲型副伤寒患者血清C 反应蛋白测定的临床意义。方法　对 90例甲型副伤寒患者的血清C 反应蛋白 (CRP)、血清谷丙转氨酶 (ALT)、血清谷草转氨酶 (AST)、外周血白细胞总数 (WBC)和血小板计数 (PLT)进行测定。用直线回归和相关分析CRP与其他指标的关系。结果　 87例 (96 6 7% )血清CRP升高 ,4 3例 (47 78% )血清ALT升高 ,4 6例 (5 1 11% )血清AST升高 ,2 7例 (30 % )血白细胞计数下降 ,2 4例 (2 6 6 7% )血小板计数下降。显示血清CRP浓度与ALT呈低度正直线相关 (r=0 2 4 5 ,P <0 0 1) ,CRP浓度与AST呈中度正直线相关 (r=0 5 72 ,P <0 0 1) ,CRP浓度与血PLT计数呈低度负直线相关 (r=0 2 5 8,P <0 0 5 ) ,CRP浓度与WBC总数不存在直线相关关系 (r=0 10 5 ,P =0 32 6 )。结论　甲型副伤寒中血清CRP升高为一重要指标 ,结合肝功能异常、血小板计数下降及流行病学资料则有助于确立诊断。

Diagnostic value of serum C-reactive protein for paratyphoid fever caused by salmonella paratyphi A

Objective To evaluate diagnostic value of serum C-reactive protein(CRP) for paratyphoid fever caused by Salmonella paratyphi A.Method The level of serum CRP,serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),peripheral blood white blood cell(WBC) and platelet(PLT)count were measured in 90 cases of paratyphoid fever caused by Salmonella paratyphi A.All data were analyzed by linear regression and correlation.Results Increased serum CRP,ALT,AST were observed in 87(96.67%),43(47.78%),46(51.11%) cases respectively,decreased peripheral blood WBC,PLT count were observed in 27(30%),24(26.67%) cases respectively.Serum CRP was low positive linear correlated to ALT(r=0.245 P<0.05),and medium positive linear correlated to AST(r=0.572,P<0.01).Serum CRP was low negative linear correlated to PLT count in peripheral blood(r=0.258,P<0.05).Serum CRP was not linear correlated to WBC count in peripheral blood(r=0.105,P<0.326).Conclusion Increased serum CRP,combined with liver lesion,decreased PLT count in peripheral blood and epidemiology indicate intection of Salmonella paratyphi A.