Targeting HIV latency: resting memory T cells,hematopoietic progenitor cells and future directions |
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Affiliation: | 1. Program in Cellular and Molecular Biology, University of Michigan,Ann Arbor, MI 48109, USA;2. Medical Scientist Training Program, University of Michigan,Ann Arbor, MI 48109, USA &3. |
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Abstract: | Current therapy for HIV effectively suppresses viral replication and prolongs life, but the infection persists due, at least in part, to latent infection of long-lived cells. One favored strategy toward a cure targets latent virus in resting memory CD4+ T cells by stimulating viral production. However, the existence of an additional reservoir in bone marrow hematopoietic progenitor cells has been detected in some treated HIV-infected people. This review describes approaches investigators have used to reactivate latent proviral genomes in resting CD4+ T cells and hematopoietic progenitor cells. In addition, the authors review approaches for clearance of these reservoirs along with other important topics related to HIV eradication. |
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Keywords: | antiviral therapy HDAC inhibitors hematopoietic progenitor cells HIV latency HIV/AIDS resting memory CD4+ T cells |
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