| 头孢西丁钠中甲醇残留量的顶空毛细管GC法测定 |
| |
| 引用本文： | 黄仕璋,王蓓. 头孢西丁钠中甲醇残留量的顶空毛细管GC法测定[J]. 中国医药工业杂志, 2007, 38(10): 727-728 |
| |
| 作者姓名： | 黄仕璋 王蓓 |
| |
| 作者单位： | 深圳信立泰药业有限公司,广东深圳,518104 |
| |
| 摘 要： | 建立了顶空毛细管GC法测定头孢西丁钠中甲醇残留量，并探讨了药物结构中甲氧基对测定的影响。采用DM-624石英毛细管柱，检测器为FID。甲醇在0．02～5mg／ml浓度范围内，与峰面积线性关系良好（r=0．9999）。方法平均回收率为97．7％，RSD为1．8％。
|
| 关 键 词： | 头孢西丁钠 甲氧基 甲醇 顶空毛细管气相色谱 有机溶剂残留 测定 |
| 文章编号： | 1001-8255（2007）10-0727-02 |
| 修稿时间： | 2007-06-15 |
Determination of Methanol in Cefoxitin Sodium by Capillary GC with Headspace Injection |
| |
| HUANG Shi-zhang,WANG Bei. Determination of Methanol in Cefoxitin Sodium by Capillary GC with Headspace Injection[J]. , 2007, 38(10): 727-728 |
| |
| Authors: | HUANG Shi-zhang WANG Bei |
| |
| Affiliation: | Shenzhen Salubris Pharmaceuticals Co., Ltd., Shenzhen 518104 |
| |
| Abstract: | A capillary GC method with headspace injection was established for the determination of methanol residual in cefoxitin sodium. The influence of methoxy group in the structure was discussed. A quartz capillary column DM-624 was used with flame ionization detector. The calibration curve of methanol was linear in the concentration range of 0.02 - 5mg/ml. The average recovery was 97.7 %, with RSD of 1.8 %. |
| |
| Keywords: | cefoxitin sodium methoxy group methanol headspace GC residual solvent determination |
| 本文献已被 维普 万方数据 等数据库收录！ |
