The role of inflammation in nonspecific abdominal aortic aneurysm disease |
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Authors: | Colleen M Brophy MD Jeffrey M Reilly MD G J Walker Smith MD M David Tilson MD |
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Institution: | (1) Department of Surgery, New England Deaconess Hospital, Harvard Surgical Service, Boston, Massachusetts;(2) Department of Surgery, Yale University, New Haven, Connecticut;(3) Department of Pathology, Yale University, New Haven, Connecticut;(4) Department of Surgery, Roosevelt/St. Luke's Hospital, New York, New York |
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Abstract: | The predominant pathologic feature of abdominal aortic aneurysm is elastin destruction, and elastin destruction may be mediated
by inflammation. In this investigation serial sections of abdominal aortic aneurysm specimens were selectively stained to
study the relationship between inflammation and elastin degradation. In addition, soluble aortic extracts were examined for
the presence of immunoglobulins. An inflammatory infiltrate was present in 8 of 10 of the abdominal aortic aneurysm specimens
examined. The infiltrate was mononuclear, commonly located at the junction of the media and adventitia; it did not codistribute
with loss of elastin. The presence of an inflammatory component in abdominal aortic aneurysm was associated with a large amount
of immunoglobulin in soluble extracts from aneurysmal tissue compared to atherosclerotic and normal control extracts. This
study further characterizes the microscopic pathology of abdominal aortic aneurysm and describes the presence of immunoglobulin
in soluble tissue extracts. In addition, the possible role of inflammation in abdominal aortic aneurysm as it relates to protease
expression is detailed.
Presented in part at the meeting of the New England Vascular Society, September 21–22, 1989, Bretton Woods, New Hampshire. |
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Keywords: | Abdominal aortic aneurysm immunoglobulins inflammatory disease |
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