西洋参茎叶皂甙在阿霉素诱导大鼠心肌损伤中的抗氧化作用

西洋参茎叶皂甙50和100mg·kg~(-1)能明显降低阿霉素诱导的大鼠全血和心肌组织中丙二醛含量,保护超氧化物歧化酶及谷胱甘肽过氧化物酶活性。表明西洋参茎叶皂甙有抗氧化作用。

Antioxidative effect of Panax quinquefolium saponin on the myocardium injury induced by doxorubicin in rats

The present experiments were designed to investigate antioxidative effect of Panax quinquefolium saponin(PQS)on the myocardium injury induced by doxorubicin(Dox)in rats.Fifty Wistar rats weighing 200 ±s 20 g were randomly divided into 5 groups.All the rats were fed on basic ration.The group 1 was only given physiological saline.The group 2 was given ip Dox 4.5mg·kg-1·d-1×2 d.The groups 3 and 4 were given ip PQS 50 and 100 mg·kg-1·d-1×3 d respectively before giving Dox.The group 5 was given Vit E 2.5 g·kg-1 ip before Dox administration.The results suggest that the activities of glutathione peroxidase(GSH-Px)and superoxidedismutase(SOD)are significantly decreased.Malondialdehyde(MDA)is apparently increased in the group 2 compared with the group 1.The activities of GSH-Px and SOD are evidently higher and MDA is significantly lower in the groups 3,4 and 5 than in the group 2.It can be concluded that PQS has an antioxidation action.This action may related to the increase of the GSH-Px and SOD activities.