极早发型炎症性肠病的特点与治疗

炎症性肠病（IBD）是一种病因不明的慢性非特异性肠道炎症性疾病。该疾病包括3种主要类型：克罗恩病（CD）、溃疡性结肠炎（UC）和未分型IBD（IBD-U）。IBD在成人中发病率高，但近年来，IBD在儿童中发病率越来越高。极早发型IBD（VEO-IBD）是儿童IBD的一部分，有其独特的表型和遗传学特征，通常病情严重，并且对常规IBD治疗效果差。该文对VEO-IBD的临床特点、发病机制和治疗进行了综述。

Features and management of very early onset inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease of unknown etiology. This disease includes three main types:Crohn''s disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U). IBD is frequently presented in adults, but in recent years, there is a rising incidence in pediatric populations. Very early onset IBD (VEO-IBD) is a fraction of pediatric IBD, but they have exclusive phenotypic and genetic characteristics such that they are accompanied by severe disease course and resistance to conventional therapy. The purpose of this review is to provide a contemporary overview of the clinical features, pathogenesis, and management of VEO-IBD.